Evidence map›Paper›PMID 41683874›Full record

ReviewInternational journal of molecular sciences2026

Microbiome Signatures in Advanced Gastric Cancer: Emerging Biomarkers for Risk Stratification, Therapy Guidance, and Prognostic Insight.

Kyung-Il John Kim, Hannah Zhong, Derek Tai, Pranati Shah, Daniel Park, Vitor Goes, Jianan Li, Claire Jung, Lucas Kim, Sofia Guzman and 2 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kyung-Il John KimDepartment of Internal Medicine, Kaiser Permanente Fontana Medical Center, 9961 Sierra Ave., Fontana, CA 92335, USA.ORCID 0009-0000-7713-3440
Hannah ZhongDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, 1500 E Duarte Rd., Duarte, CA 91010, USA.
Derek TaiDepartment of Internal Medicine, Loma Linda University Medical Center, 11234 Anderson St., Loma Linda, CA 92354, USA.ORCID 0000-0002-6461-5560
Pranati ShahDepartment of Internal Medicine, Loma Linda University Medical Center, 11234 Anderson St., Loma Linda, CA 92354, USA.ORCID 0009-0003-0331-892X
Daniel ParkDepartment of Hematology and Oncology, Harbor-UCLA Medical Center, 1000 W Carson St., Torrance, CA 90502, USA.
Vitor GoesDepartment of Internal Medicine, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627-Morumbi, São Paulo 05652-900, SP, Brazil.ORCID 0000-0003-3521-6496
Jianan LiFaculty of Kinesiology & Physical Education, University of Toronto, 100 Devonshire Place, Toronto, ON M5S 2C9, Canada.
Claire JungFlintridge Preparatory School, 4543 Crown Ave., La Cañada Flintridge, CA 91011, USA.
Lucas KimSchool of Medicine, Loma Linda University, 11175 Campus St., Loma Linda, CA 92350, USA.
Sofia GuzmanDepartment of Medical Oncology and Therapeutics Research, City of Hope, 1500 E Duarte Rd., Duarte, CA 91010, USA.
Gagandeep BrarDepartment of Medical Oncology and Therapeutics Research, City of Hope, 1500 E Duarte Rd., Duarte, CA 91010, USA.
Dani CastilloDepartment of Medical Oncology and Therapeutics Research, City of Hope, 1500 E Duarte Rd., Duarte, CA 91010, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC), often diagnosed at advanced or metastatic stages, remains a significant clinical challenge requiring novel biomarkers for early detection, risk stratification, and effective, personalized treatment optimization. Emerging evidence underscores a strong association between gut microbiome dysbiosis and GC initiation, progression, and therapeutic outcomes. This review explores the potential of the advanced/metastatic gastric microbiome as a source of diagnostic and targetable biomarkers and its role in modulating responses to immunotherapy. Although

Indexed as

Biomarkers, TumorGastrointestinal MicrobiomeStomach NeoplasmsAnimalsDysbiosisHelicobacter InfectionsHumansImmunotherapyPrognosisRisk AssessmentBiomarkers, Tumoradvanced gastric cancerbiomarkersgastric cancergastric microbiome

Identifiers

PMID41683874
PMCPMC12898107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.