Evidence map›Paper›PMID 41683861›Full record

ArticleInternational journal of molecular sciences2026

Transplantation of Soluble Epoxide Hydrolase Inhibitor-Treated Human Brown Adipocytes Promotes Adipose Tissue Activation in High-Fat-Diet-Fed Nude Mice.

Haoying Wu, Xinyun Xu, Jiangang Chen, Christophe Morisseau, Bruce D Hammock, Yu-Hua Tseng, Ling Zhao

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haoying WuDepartment of Nutrition, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0009-0005-3814-0679
Xinyun XuDepartment of Nutrition, University of Tennessee, Knoxville, TN 37996, USA.
Jiangang ChenDepartment of Public Health, University of Tennessee, Knoxville, TN 37996, USA.
Christophe MorisseauDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA.ORCID 0000-0002-5672-6631
Bruce D HammockDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA.ORCID 0000-0003-1408-8317
Yu-Hua TsengJoslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2053-9559
Ling ZhaoDepartment of Nutrition, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0002-8297-7039

Funding

Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
n-3 PUFA derived epoxides and thermogenesis for obesity preventionR15DK132728 · NIDDK · UNIVERSITY OF TENNESSEE KNOXVILLE · PI ZHAO, LING · 2022 to 2022
$446k
Breakthrough T1D #3-SRA-2023-1362-S-BNIDDK NIH HHS R15 DK132728NIEHS NIH HHS R35 ES030443NIH HHS 1R15DK132728-00NIH HHS 1R35ES030443-00NIH HHS 1R35GM146983-00
6 · The paper itself

Abstract

Brown adipose tissue (BAT) plays a key role in non-shivering thermogenesis and is a promising target for enhancing energy expenditure to combat obesity. Soluble epoxide hydrolase (sEH) is a cytosolic enzyme that catalyzes the conversion of epoxy fatty acids into less active diols. We have reported that local administration of the sEH inhibitor,

Indexed as

Adipocytes, BrownAdipose Tissue, BrownDiet, High-FatEnzyme InhibitorsEpoxide HydrolasesAnimalsCell DifferentiationHumansLipid MetabolismMaleMiceMice, NudeObesityThermogenesisEnzyme InhibitorsEpoxide Hydrolaseshuman brown adipocytesEH inhibitort-AUCBthermogenic activationtransplantation

Identifiers

PMID41683861
PMCPMC12898555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.