Evidence map›Paper›PMID 41683815›Full record

ArticleInternational journal of molecular sciences2026

Identification of Basement Membrane-Related Biomarkers in the Progression of Cutaneous Squamous Cell Carcinoma.

Shuaijun Zou, Sijia Huang, Jun Liu, Ruiqian Yao, Xiaoyan Yang, Haixia Zhao, Lin Du, Liangzhe Wang, Yuanjie Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuaijun ZouDepartment of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.ORCID 0000-0002-6504-7024
Sijia HuangSchool of Medicine, Shanghai University, Shanghai 200444, China.
Jun LiuDepartment of Naval Diving Medicine, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.
Ruiqian YaoDepartment of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.ORCID 0009-0007-6118-1879
Xiaoyan YangDepartment of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.
Haixia ZhaoDepartment of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.
Lin DuDepartment of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.
Liangzhe WangDepartment of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.
Yuanjie ZhuDepartment of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.

Funding

National Natural Science Foundation of China 82402580
6 · The paper itself

Abstract

Basement membrane (BM) breaching is a critical hallmark of cutaneous squamous cell carcinoma (cSCC) invasion. This study aimed to identify novel BM-related genes (BMRGs) to effectively distinguish invasive cSCC from actinic keratosis (AK) and Bowen's disease (BD), and to identify potential therapeutic targets. Single-cell RNA sequencing was used for BMRGs identification within keratinocytes and fibroblasts clusters. Protein-protein interaction network analysis and Lasso regression were performed for hub BMRGs screening, together with nomogram model construction and validation. In this study, 6-9 central hub BMRGs were identified for each stage during cSCC progression with a good AUC value (>0.8). In keratinocytes, BMRGs such as integrins (

Indexed as

Basement MembraneBiomarkers, TumorCutaneous Squamous Cell CarcinomaSkin NeoplasmsBowen's DiseaseDisease ProgressionFibroblastsGene Expression Regulation, NeoplasticHumansKeratinocytesKeratosis, ActinicProtein Interaction MapsBiomarkers, Tumoractinic keratosisbasement membrane-related genesbiomarkersBowen’s diseasecutaneous squamous cell carcinoma

Identifiers

PMID41683815
PMCPMC12898604

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.