Hypoxia-Driven Pulmonary Adaptation in the Yak: A Homeostatic Mechanism Mediated by Cell Adhesion Molecules.

Huizhen Wang, Nating Huang, Xun Zhang, Jingqing Ma, Xiaorong Liu, Jiarui Chen, Qing Wei

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Huizhen WangCollege of Eco-Environmental Engineering, Qinghai University, Xining 810016, China.

Nating HuangCollege of Eco-Environmental Engineering, Qinghai University, Xining 810016, China.

Xun ZhangCollege of Eco-Environmental Engineering, Qinghai University, Xining 810016, China.

Jingqing MaCollege of Eco-Environmental Engineering, Qinghai University, Xining 810016, China.

Xiaorong LiuCollege of Eco-Environmental Engineering, Qinghai University, Xining 810016, China.

Jiarui ChenCollege of Eco-Environmental Engineering, Qinghai University, Xining 810016, China.

Qing WeiCollege of Eco-Environmental Engineering, Qinghai University, Xining 810016, China.

Funding

the Qinghai Provincial Science and Technology Department Basic Research Project 2023-ZJ-708

6 · The paper itself

Abstract

Cell adhesion molecules (CAMs) are key regulators of tissue structural integrity and functional coordination, yet their specific role in the adaptation of yak lung tissue to high-altitude hypoxia remains unelucidated. Thus, we employed transcriptomic sequencing (RNA-seq), molecular biology assays, and single-cell RNA-seq (scRNA-seq) to analyze the expression characteristics of CAMs in yak lung tissues at high and low altitudes. Trypsin or collagenase digestion showed higher cell counts in high-altitude yak lungs (

Indexed as

Adaptation, PhysiologicalCell Adhesion MoleculesHomeostasisHypoxiaLungAltitudeAnimalsCattleGene Expression ProfilingGene Expression RegulationCell Adhesion Moleculesadaptation to high-altitude environmentscell adhesion moleculesyak lung tissue

Identifiers

PMID41683789

DOI10.3390/ijms27031368

PMCPMC12897801

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.