Evidence map›Paper›PMID 41683728›Full record

ArticleInternational journal of molecular sciences2026

Cord Blood Serum Attenuates Hyperosmolarity-Induced Inflammation and TRPV1 Upregulation in Conjunctival Epithelial Cells.

Gloria Astolfi, Carmen Ciavarella, Chiara Coslovi, Elisa Bergantin, Marina Buzzi, Luigi Fontana, Piera Versura

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gloria AstolfiOphthalmology Unit, DIMEC, Alma Mater Studiorum Università di Bologna, 40138 Bologna, Italy.ORCID 0000-0003-2079-5261
Carmen CiavarellaOphthalmology Unit, DIMEC, Alma Mater Studiorum Università di Bologna, 40138 Bologna, Italy.ORCID 0000-0001-6465-9945
Chiara CosloviOphthalmology Unit, DIMEC, Alma Mater Studiorum Università di Bologna, 40138 Bologna, Italy.
Elisa BergantinEmilia Romagna Cord Blood Bank, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Marina BuzziEmilia Romagna Cord Blood Bank, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-3711-5886
Luigi FontanaOphthalmology Unit, DIMEC, Alma Mater Studiorum Università di Bologna, 40138 Bologna, Italy.
Piera VersuraOphthalmology Unit, DIMEC, Alma Mater Studiorum Università di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-2951-5337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eye drops derived from human blood components (Eye Drops of Human Origin-EDHO) have proven effective in reducing ocular pain associated with severe keratopathies. Among these, Cord Blood Serum (CBS) is particularly promising for its high content of growth and neurotrophic factors. This study evaluated the ability of CBS to modulate inflammatory and nociceptive activation in the human conjunctival epithelial cell (HCEC) line exposed to hyperosmotic stress. CBS batches were characterized for brain-derived neurotrophic factor (BDNF) content and classified as CBS

Indexed as

ConjunctivaEpithelial CellsFetal BloodInflammationTRPV Cation ChannelsCell LineCell SurvivalHumansOsmolar ConcentrationOsmotic PressureUp-RegulationTRPV1 protein, humanTRPV Cation Channelsconjunctival epithelial cellscord blood serumHLA-DRhyperosmolar stressinflammationpain modulationTRPV1 nociception

Identifiers

PMID41683728
PMCPMC12898548

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.