Evidence map›Paper›PMID 41683723›Full record

ArticleInternational journal of molecular sciences2026

Reanimation of Stored Tissue Biopsies: A Functional Study and Translational Approach.

Veronica Alfano, Gabriele Ruffolo, Antonella Spila, Maria Giovanna Valente, Luigi Sansone, Manuel Belli, Dania Ramadan, Chiara Miele, Luca Garelli, Leonardo Lupacchini and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Veronica AlfanoIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0009-0007-4465-3133
Gabriele RuffoloIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0002-6554-5496
Antonella SpilaIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0002-7678-5428
Maria Giovanna ValenteIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0003-0093-173X
Luigi SansoneIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0003-3150-6461
Manuel BelliIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0001-9183-6206
Dania RamadanIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0009-0005-7786-2367
Chiara MieleIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0009-0006-6539-9755
Luca GarelliIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0003-4310-7011
Leonardo LupacchiniIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0002-9172-7461
Patrizia FerroniIRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0002-9877-8712
Daniela MerloDepartment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-4240-5762
Eleonora PalmaDepartment of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6026-927X
Fiorella GuadagniDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma University, Via di Val Cannuta, 247, 00166 Rome, Italy.ORCID 0000-0003-3652-0457

Funding

European Project Horizon 2020 SC1-BHC-02-2019 (REVERT) 848098Italian Ministry of Health (Ricerca Corrente) 10/2502
6 · The paper itself

Abstract

The availability of biobanked tissues represents an important resource for translational research; however, functional investigations are generally limited to freshly collected samples. To address this limitation, we developed an innovative strategy to restore functional properties of frozen biopsies by microtransplanting patient-derived membrane proteins into

Indexed as

Colonic NeoplasmsAnimalsBiopsyCell MembraneChloride ChannelsFemaleHumansNeurotransmitter AgentsOocytesTranslational Research, BiomedicalXenopus laevisChloride ChannelsNeurotransmitter Agentscancerfunctional studyion channelsmicrotransplantationtranslational approachXenopus oocyte model

Identifiers

PMID41683723
PMCPMC12898366

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.