Evidence map›Paper›PMID 41683716›Full record

SynthesisInternational journal of molecular sciences2026

The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review.

Rimsha Kanwal, Bilal Jawed, Syed Khuram Zakir, Francesco Gaudio, Riccardo Martinotti, Matteo Botteghi, Stefano Martinotti, Elena Toniato

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rimsha KanwalCentre of Advanced Studies and Technology, Department of Innovative Technology in Medicine and Dentistry, University of Chieti, 66100 Chieti, Italy.
Bilal JawedCentre of Advanced Studies and Technology, Department of Innovative Technology in Medicine and Dentistry, University of Chieti, 66100 Chieti, Italy.
Syed Khuram ZakirCentre of Advanced Studies and Technology, Department of Innovative Technology in Medicine and Dentistry, University of Chieti, 66100 Chieti, Italy.
Francesco GaudioUnit of Haematology, F. MiulliUniversity Hospital, LUM University, 70021 Acquaviva delle Fonti, Italy.ORCID 0000-0002-7817-1665
Riccardo MartinottiResidency Program in Clinical Oncology, Faculty of Medicine, Umberto I University Hospital, University of Rome "La Sapienza", 00185 Rome, Italy.
Matteo BotteghiExperimental Pathology Research Group, Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, 60121 Ancona, Italy.ORCID 0009-0007-9725-1277
Stefano MartinottiUnit of Clinical Pathology, Department of Medicine and Surgeon, F. Miulli University Hospital, LUM University, Casamassima, 70010 Bari, Italy.ORCID 0000-0001-7672-891X
Elena ToniatoCentre of Advanced Studies and Technology, Department of Innovative Technology in Medicine and Dentistry, University of Chieti, 66100 Chieti, Italy.

Funding

University of G'd Annunzio Chieti-Pescara Ateneo ex 60%
6 · The paper itself

Abstract

Metastasis is the leading cause of cancer-related mortality. Although aspirin has been associated with reduced metastatic risk, existing evidence is fragmented across experimental systems, and a comprehensive mechanistic synthesis remains lacking. In particular, the relative contributions of platelet aggregation, thromboxane A

Indexed as

AspirinNeoplasm MetastasisNeoplasmsAnimalsEpithelial-Mesenchymal TransitionHumansPlatelet AggregationSignal TransductionThromboxane A2AspirinThromboxane A2aspirincancer metastasiscyclooxygenase-1 (COX-1)epithelial mesenchymal transition (EMT)immune modulationplatelet activationthromboxane A2 (TXA2)

Identifiers

PMID41683716
PMCPMC12897594

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.