Evidence map›Paper›PMID 41683711›Full record

ArticleInternational journal of molecular sciences2026

Notch Signalling Plays a Role in Patterning the Ventral Mesoderm During Early Embryogenesis in

Marvel Megaly, Gregory Foran, Arsala Ali, Anel Turgambayeva, Tai Sengsouriya, Samantha Berube, Ryan Douglas Hallam, Ping Liang, Aleksandar Necakov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marvel MegalyBiological Sciences Department, Brock University, St. Catharines, ON L2S 3A1, Canada.
Gregory ForanNeuroscience Department, Baylor College of Medicine, Houston, TX 77030, USA.
Arsala AliBiological Sciences Department, Brock University, St. Catharines, ON L2S 3A1, Canada.
Anel TurgambayevaBiological Sciences Department, Brock University, St. Catharines, ON L2S 3A1, Canada.
Tai SengsouriyaBiological Sciences Department, Brock University, St. Catharines, ON L2S 3A1, Canada.
Samantha BerubeBiological Sciences Department, Brock University, St. Catharines, ON L2S 3A1, Canada.
Ryan Douglas HallamBiological Sciences Department, Brock University, St. Catharines, ON L2S 3A1, Canada.
Ping LiangBiological Sciences Department, Brock University, St. Catharines, ON L2S 3A1, Canada.ORCID 0000-0003-4423-0636
Aleksandar NecakovBiological Sciences Department, Brock University, St. Catharines, ON L2S 3A1, Canada.ORCID 0000-0001-7080-2859

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2018-06781 NSERC
6 · The paper itself

Abstract

Notch signalling is a critical regulator of multiple developmental processes through its ability to control gene expression and thereby influence cell fate specification and cell proliferation through direct cell-cell communication. Although Notch signalling has been implicated in myogenesis during late embryogenesis, its role in early mesoderm development has been largely unexplored. Endocytosis of the Notch ligand Delta and the Notch receptor extracellular domain, a critical step in Notch pathway activation, has been extensively observed in the ventral mesoderm of the early

Indexed as

Body PatterningDrosophila melanogasterDrosophila ProteinsEmbryonic DevelopmentMesodermReceptors, NotchSignal TransductionAnimalsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalDrosophila ProteinsReceptors, NotchdevelopmentDrosophila melanogasterembryogenesisgastrulationgeneticsNotch signalling

Identifiers

PMID41683711
PMCPMC12898112

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.