Evidence map›Paper›PMID 41683674›Full record

ArticleInternational journal of molecular sciences2026

Elevated Na

Yuma Mizuno, Shiyue Pan, Tong Zhou, Patrick G Kehoe, Yumei Feng Earley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yuma MizunoDepartment of Physiology and Cell Biology, University of Nevada, Reno, NV 89557, USA.ORCID 0009-0008-0628-2009
Shiyue PanDepartment of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Tong ZhouDepartment of Physiology and Cell Biology, University of Nevada, Reno, NV 89557, USA.
Patrick G KehoeCerebrovascular and Dementia Research Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UK.ORCID 0000-0002-7542-1139
Yumei Feng EarleyDepartment of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-4138-0105

Funding

TRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5M
The Neural Mechanisms of HypertensionR01HL122770 · NHLBI · UNIVERSITY OF ROCHESTER · PI FENG EARLEY, YUMEI · 2015 to 2023
$4.2M
Neural mechanisms regulating glucose homeostasisR01DK135621 · NIDDK · UNIVERSITY OF ROCHESTER · PI Yumei Feng Earley · 2023 to 2026
$2.2M
NHLBI NIH HHS R01 HL122770NHLBI NIH HHS R35 HL155008NIDDK NIH HHS R01 DK135621NIH HHS 1R01DK135621-27NIH HHS 1R01HL122770-26NIH HHS 1R35HL155008-28
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and the accumulation of amyloid plaques and neurofibrillary tangles. While prior research has focused mainly on protein aggregation and neuroinflammation, emerging evidence suggests that ionic imbalances, particularly involving sodium (Na

Indexed as

Alzheimer DiseaseBiomarkersPotassiumSodiumAgedAged, 80 and overDisease ProgressionFemaleHumansMaleBiomarkersPotassiumSodiumAlzheimer’s diseasebrain sodiumcerebrospinal fluid sodiumNa+/K+ ratio

Identifiers

PMID41683674
PMCPMC12898237

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.