Evidence map›Paper›PMID 41683657›Full record

ArticleInternational journal of molecular sciences2026

Circulating Exosomal MicroRNA Profiles Associated with Heavy Metal Exposure and Short Stature in Children.

Min Won Shin, Heeji Kim, Seongho Ryu, Shin-Hye Kim

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Min Won ShinDepartment of Pediatrics, Inje University Sanggye Paik Hospital, Seoul 01757, Republic of Korea.
Heeji KimSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.ORCID 0009-0004-3431-2157
Seongho RyuSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.
Shin-Hye KimDepartment of Pediatrics, Inje University Sanggye Paik Hospital, Seoul 01757, Republic of Korea.ORCID 0000-0003-0413-122X

Funding

National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) RS-2023-00209827
6 · The paper itself

Abstract

Heavy metal exposure is increasingly linked to impaired childhood growth, but the biological mechanisms are poorly understood. Here, we assessed associations between heavy metal exposure and growth impairment (idiopathic short stature [ISS] and growth hormone deficiency [GHD]) in 36 children (24 cases, 12 controls, males 41.7%), identifying related alterations in circulating exosomal miRNAs. Blood/urine concentrations of nine metals, including Pb, As, and Hg were measured, and serum exosomal miRNAs were profiled via sequencing. Elevated heavy metal exposure was associated with significantly increased proportions of ISS and GHD. Specifically, high blood Pb was associated with ISS (

Indexed as

Circulating MicroRNADwarfismEnvironmental ExposureExosomesGrowth DisordersMetals, HeavyMicroRNAsCase-Control StudiesChildFemaleHuman Growth HormoneHumansInsulin-Like Growth Factor IMaleCirculating MicroRNAHuman Growth HormoneInsulin-Like Growth Factor IMetals, HeavyMicroRNAsAsendochondral ossificationgrowth hormone deficiencyheavy metalsHgidiopathic short staturemicroRNAPbshort stature

Identifiers

PMID41683657
PMCPMC12898619

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.