Evidence map›Paper›PMID 41683646›Full record

ArticleInternational journal of molecular sciences2026

Untargeted Serum Proteomics in the Fontan Circulation Reveals Three Distinct Molecular Signatures of Fontan Physiology with CYB5R3 Among Key Proteins.

Alexander Blaha, David Renaud, Fatima Ageed, Bettina Sarg, Klaus Faserl, Alexander Kirchmair, Dietmar Rieder, Isabel Mihajlovic, Nele Ströbel, Kai Thorsten Laser and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Omics Technologies in Molecular Biology.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander BlahaDepartment of Child and Adolescent Health, Division of Pediatrics III-Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0009-0000-6086-3308
David RenaudDepartment of Child and Adolescent Health, Division of Pediatrics III-Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0009-0003-8746-5758
Fatima AgeedDepartment of Child and Adolescent Health, Division of Pediatrics III-Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0009-0008-8066-9658
Bettina SargBiocenter, Protein Core Facility, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Klaus FaserlBiocenter, Protein Core Facility, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-1646-3256
Alexander KirchmairBiocenter, Bioinformatics Core Facility, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-2284-7424
Dietmar RiederBiocenter, Institute of Bioinformatics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-1754-690X
Isabel MihajlovicDepartment of Child and Adolescent Health, Division of Pediatrics III-Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Nele StröbelDepartment of Child and Adolescent Health, Division of Pediatrics III-Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Kai Thorsten LaserDepartment of Pediatrics and Adolescent Medicine, University Hospital of Giessen and Marburg, 35392 Giessen, Germany.
Miriam MichelDepartment of Child and Adolescent Health, Division of Pediatrics III-Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-3626-3270

Funding

FWF Austrian Science Fund (10.55776/KLI1036)FWF Austrian Science Fund 10.55776/KLI1036
6 · The paper itself

Abstract

The total cavopulmonary anastomosis (Fontan procedure), a palliative procedure for single-ventricle congenital heart disease, improves survival but is associated with progressive multiorgan complications and high long-term morbidity. Prior blood-based proteomic studies in adults have been limited to targeted antibody-based panels or focused on methodological comparisons. Systemic molecular alterations in younger, clinically heterogeneous patients, particularly in untargeted pathways, remain incompletely characterized. Serum samples from 48 Fontan patients and 48 age- and sex-matched healthy controls were analyzed using mass spectrometry with TMT labeling. 2228 proteins were quantified, of which 124 were significantly differentially abundant (fold change > 1.5 or <0.67, FDR-adjusted

Indexed as

Cytochrome-B(5) ReductaseFontan ProcedureHeart Defects, CongenitalProteomeProteomicsAdolescentBiomarkersChildChild, PreschoolFemaleHumansMaleBiomarkersCytochrome-B(5) ReductaseProteomebiomarkerscongenital heart diseaseCYB5R3Fontanmass spectrometryproteomicsrisk stratificationsingle ventricle

Identifiers

PMID41683646
PMCPMC12897359

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.