Evidence map›Paper›PMID 41683630›Full record

ArticleInternational journal of molecular sciences2026

Intraclonal Enrichment of IL-23 Receptor Complex Expression in the Proliferative Fraction of Chronic Lymphocytic Leukemia.

Martina Cardillo, Fabiana Ferrero, Nadia Bertola, Ennio Nano, Rosanna Massara, Maria Cristina Capra, Daniele Reverberi, Monica Colombo, Vanessa Cossu, Fabio Ghiotto and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Martina CardilloDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-0386-6611
Fabiana FerreroDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.ORCID 0009-0000-5097-6640
Nadia BertolaMolecular Pathology Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genoa, Italy.ORCID 0000-0003-4591-3260
Ennio NanoMolecular Pathology Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genoa, Italy.ORCID 0009-0003-1479-8121
Rosanna MassaraMolecular Pathology Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genoa, Italy.
Maria Cristina CapraMolecular Pathology Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genoa, Italy.
Daniele ReverberiMolecular Pathology Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genoa, Italy.
Monica ColomboMolecular Pathology Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genoa, Italy.ORCID 0000-0001-5512-8106
Vanessa CossuDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-7302-7429
Fabio GhiottoDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-2301-8698
Adalberto IbaticiHematology and Cellular Therapy Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genova, Italy.
Emanuele AngelucciHematology and Cellular Therapy Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genova, Italy.ORCID 0000-0002-6512-6080
Antonino NeriScientific Directorate, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Massimo GentileHematology Unit, Department of Onco-Hematology, AO of Cosenza, 87100 Cosenza, Italy.ORCID 0000-0002-5256-0726
Fortunato MorabitoGruppo Amici Dell'Ematologia Foundation-GrADE, 42100 Reggio Emilia, Italy.ORCID 0000-0002-2585-7073
Andrea Nicola MazzarelloDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
Manlio FerrariniDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
Franco FaisDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-6643-7083
Giovanna CutronaMolecular Pathology Unit, IRCCS Azienda Ospedaliera Metroplitana, 16132 Genoa, Italy.ORCID 0000-0002-3335-1101

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is a dynamic malignancy in which intraclonal subfractions differ in activation history and responsiveness to microenvironmental signals. Here, we investigated the expression and inducibility of IL-12 family receptor subunits (IL-23R, IL-12Rβ1, IL-12Rβ2) and the related receptor complexes in recirculating CLL cells, with a focus on CXCR4/CD5-defined fractions: the proliferative fraction (PF; CXCR4

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellReceptors, InterleukinCD5 AntigensCell ProliferationHumansReceptors, CXCR4Receptors, Interleukin-12CD5 AntigensIL23R protein, humanReceptors, CXCR4Receptors, InterleukinReceptors, Interleukin-12antigen-independent stimulationchronic lymphocytic leukemiaIL-12 receptor complexIL-23 receptor complexTLR-9

Identifiers

PMID41683630
PMCPMC12898115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.