Evidence map›Paper›PMID 41683624›Full record

ArticleInternational journal of molecular sciences2026

Synthesis, Biological Evaluation, and Computational Analysis of 1,4-Naphthoquinone Derivatives as Inhibitors of the Sodium-Dependent NADH:Ubiquinone Oxidoreductase (NQR) in

Zachary J Liveris, Ming Yuan, Yuyao Hu, Jennifer M Sorescu, Karina Tuz, Oscar X Juárez, Daniel P Becker

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zachary J LiverisDepartment of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA.ORCID 0009-0008-8749-5494
Ming YuanDepartment of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.
Yuyao HuDepartment of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.ORCID 0000-0003-0539-0450
Jennifer M SorescuDepartment of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.ORCID 0000-0003-2555-2760
Karina TuzDepartment of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.
Oscar X JuárezDepartment of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.
Daniel P BeckerDepartment of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA.ORCID 0000-0001-9392-0460

Funding

DEVELOPMENT OF A NOVEL CLASS OF ANTIBIOTICS AGAINST VIBRIO CHOLERAE NA+-NQRR01AI151152 · NIAID · ILLINOIS INSTITUTE OF TECHNOLOGY · PI JUAREZ, OSCAR · 2022 to 2025
$2.1M
NIAID NIH HHS R01 AI151152NIH HHS R01AI151152
6 · The paper itself

Abstract

The therapeutic efficacy of antibiotics has been significant in extending human life expectancy by combating virulent bacterial infections. Nevertheless, multidrug-resistant (MDR) microorganisms remain a global crisis as these bacteria have developed resistance to conventional antibacterial agents. An unexplored antibiotic target found exclusively in bacteria is the Na

Indexed as

Anti-Bacterial AgentsBacterial ProteinsElectron Transport Complex IEnzyme InhibitorsNaphthoquinonesVibrio choleraeMicrobial Sensitivity TestsMolecular Docking Simulation1,4-naphthoquinoneAnti-Bacterial AgentsBacterial ProteinsElectron Transport Complex IEnzyme InhibitorsNaphthoquinonesantibioticcholeranaphthoquinoneNQRsodium-dependent NADH:ubiquinone oxidoreductase

Identifiers

PMID41683624
PMCPMC12898190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.