Evidence map›Paper›PMID 41683585›Full record

ArticleInternational journal of molecular sciences2026

Molecular Basis of Surfactin-Induced Macrophage Modulation and Its Implications in Medication-Related Osteonecrosis of the Jaw Pathogenesis.

Yuki Kodama-Maruyama, Hiroki Tsurushima, Ayaka Koga, Yoshie Nagai-Yoshioka, Ryota Yamasaki, Manabu Habu, Izumi Yoshioka, Wataru Ariyoshi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuki Kodama-MaruyamaDivision of Infections and Molecular Biology, Department of Advanced Pathophysiological Science, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.
Hiroki TsurushimaDivision of Oral Medicine, Department of Oral and Maxillofacial Disease Control, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0009-0000-9426-184X
Ayaka KogaDivision of Infections and Molecular Biology, Department of Advanced Pathophysiological Science, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0009-0008-6259-6432
Yoshie Nagai-YoshiokaDivision of Infections and Molecular Biology, Department of Advanced Pathophysiological Science, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0009-0004-2615-6545
Ryota YamasakiDivision of Infections and Molecular Biology, Department of Advanced Pathophysiological Science, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0000-0003-1152-3248
Manabu HabuDivision of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Disease Control, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0000-0002-6586-2539
Izumi YoshiokaDivision of Oral Medicine, Department of Oral and Maxillofacial Disease Control, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.
Wataru AriyoshiDivision of Infections and Molecular Biology, Department of Advanced Pathophysiological Science, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0000-0002-6533-5683

Funding

a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science 25K13154A Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science 23K21495The Yoshida Foundation for Academic and Educational Promotion 21H03145
6 · The paper itself

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a refractory disease for which no established treatment currently exists. Surfactin, a biosurfactant produced by

Indexed as

LipopeptidesMacrophagesOsteonecrosisPeptides, CyclicAnimalsBiosurfactantsCell LineInterleukin-6LipopolysaccharidesMiceSignal TransductionTranscription Factor AP-1Interleukin-6LipopeptidesLipopolysaccharidesPeptides, Cyclicsurfactin peptideTranscription Factor AP-1AP-1IL-6JAK/STATMAPKMRONJsurfactin

Identifiers

PMID41683585
PMCPMC12897720

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.