Evidence map›Paper›PMID 41683582›Full record

ArticleInternational journal of molecular sciences2026

Role of Periostin in the Development of Nasal Hyperresponsiveness in Mice with Allergic Rhinitis.

Yukika Adachi, Yusuke Ando, Kanade Nagaosa, Moeka Maeno, Michio Yamashita, Fumiko Takenoya, Seiji Shioda, Motohiko Hanazaki, Hiroyasu Sakai, Yoshihiko Chiba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yukika AdachiLaboratory of Molecular Biology and Physiology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Yusuke AndoLaboratory of Clinical Pathology, Faculty of Pharmacy, Josai University, 1-1 Keyakidai, Sakado 350-0295, Saitama, Japan.
Kanade NagaosaLaboratory of Molecular Biology and Physiology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Moeka MaenoLaboratory of Molecular Biology and Physiology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Michio YamashitaLaboratory of Sports Sciences, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.ORCID 0000-0001-7719-7030
Fumiko TakenoyaLaboratory of Sports Sciences, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Seiji ShiodaLaboratory of Functional Morphology, Shonan University of Medical Sciences, 16-48 Kamishinano, Totsuka-ku, Yokohama 224-0806, Kanagawa, Japan.
Motohiko HanazakiDepartment of Anesthesiology and Intensive Care Medicine, School of Medicine, International University of Health and Welfare, 4-3, Kozunomori, Narita 286-8686, Chiba, Japan.
Hiroyasu SakaiLaboratory of Toxicology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Yoshihiko ChibaLaboratory of Molecular Biology and Physiology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.ORCID 0000-0002-7342-4491

Funding

Japan Society for the Promotion of Science 24K09836Japan Society for the Promotion of Science 24K12123
6 · The paper itself

Abstract

Periostin is a matricellular protein induced by type 2 cytokines. It has been shown to play important roles in airway inflammation and tissue remodeling. Although periostin has been studied in asthma and chronic rhinosinusitis, its role in allergic rhinitis (AR) and nasal hyperresponsiveness (NHR) is unclear. This study aimed to determine whether periostin is involved in the development of NHR in AR. A murine AR model was established by sensitization and repeated intranasal challenges with Japanese cedar pollen (JCP). In this animal model of AR, an increase in nasal responsiveness to histamine was observed 24 h after the last JCP challenge, indicating the development of NHR. RT-qPCR analysis revealed that the JCP-induced NHR was accompanied by increased periostin gene expression. Immunohistochemical examinations demonstrated the expression of integrin subunits α

Indexed as

Cell Adhesion MoleculesNasal MucosaPeriostinRhinitis, AllergicAnimalsCryptomeriaDisease Models, AnimalFemaleMiceMice, Inbred BALB CPollenCell Adhesion MoleculesPeriostinPostn protein, mouseallergic rhinitisJapanese cedar pollennasal hyperresponsivenessperiostin

Identifiers

PMID41683582
PMCPMC12898203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.