Evidence map›Paper›PMID 41683560›Full record

ArticleInternational journal of molecular sciences2026

Microbiome-Derived Indole-3-Lactic Acid Attenuates

Sang Gyu Lee, Nam Hao Chau, Seoyoon Ham, Yujin Baek, Ngoc Ha Nguyen, Seon Hwa Kim, Young In Lee

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sang Gyu LeeDepartment of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0000-0002-6237-9031
Nam Hao ChauDepartment of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 17000, Vietnam.ORCID 0009-0008-5384-2603
Seoyoon HamDepartment of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0009-0002-5569-9579
Yujin BaekDepartment of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0009-0004-3463-6661
Ngoc Ha NguyenDepartment of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0009-0002-4466-9550
Seon Hwa KimBioinformatics Collaboration Unit (BiCU), Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0009-0000-3375-8705
Young In LeeDepartment of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0000-0001-6831-7379

Funding

Technology Innovation Program (or Industrial Strategic Technology Development Program-Novel microbiome therapy for hidradenitis suppurativa and severe acne based on integrative microbi-ome-multiomics approach) 20024192
6 · The paper itself

Abstract

Acne vulgaris is a chronic inflammatory dermatosis where conventional therapies often face limitations in efficacy and safety, necessitating the development of microbiome-targeted interventions. This study investigated the immunomodulatory potential of microbiome-derived tryptophan metabolites as a novel therapeutic strategy for

Indexed as

Acne VulgarisIndolesInflammationMicrobiotaPropionibacterium acnesReceptors, Aryl HydrocarbonAnimalsCytochrome P-450 CYP1A1Disease Models, AnimalHumansKeratinocytesMiceSignal TransductionSkin MicrobiomeCytochrome P-450 CYP1A1indole-3-lactic acidIndolesReceptors, Aryl Hydrocarbonacne vulgarisaryl hydrocarbonCutibacterium acnesindoleskeratinocytes

Identifiers

PMID41683560
PMCPMC12897017

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.