Evidence map›Paper›PMID 41683551›Full record

ArticleMolecules (Basel, Switzerland)2026

Synthesis, Characterization, Molecular Docking, and Preliminary Biological Evaluation of 2-((4-Morpholino-1,2,5-thiadiazol-3-yl)oxy)benzaldehyde.

Mokete Motente, Uche A K Chude-Okonkwo

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mokete MotenteInstitute for Artificial Intelligent Systems, University of Johannesburg, P.O. Box 524, Johannesburg 2092, South Africa.
Uche A K Chude-OkonkwoInstitute for Artificial Intelligent Systems, University of Johannesburg, P.O. Box 524, Johannesburg 2092, South Africa.

Funding

University of Johannesburg N/A
6 · The paper itself

Abstract

This study details the synthesis, characterization, molecular docking and preliminary biological evaluation of a new heterocyclic compound, 2-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)benzaldehyde. This molecule was designed using an artificial intelligence (AI)-based molecular generative model. It was synthesized through a nucleophilic substitution between 3-chloro-4-morpholino-1,2,5-thiadiazole and 2-hydroxybenzaldehyde. Structural elucidation was performed using

Indexed as

Antineoplastic AgentsBenzaldehydesMolecular Docking SimulationThiadiazolesCell Line, TumorCrystallography, X-RayHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsbenzaldehydeBenzaldehydesThiadiazoles2-hydroxybenzaldehyde3-chloro-4-morpholino-1,2,5-thiadiazoleartificial intelligencebiological evaluation

Identifiers

PMID41683551
PMCPMC12899471

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.