Evidence map›Paper›PMID 41683500›Full record

ReviewMolecules (Basel, Switzerland)2026

Omega Nucleic Acids (ΩNA), Ultimate Nucleic Acids for Future Technology.

Shogo Hamada, Keiji Murayama, Yusuke Takezawa, Ryojun Toyoda, Akinori Kuzuya

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shogo HamadaDepartment of Computer Science, School of Computing, Institute of Science Tokyo, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Kanagawa, Japan.ORCID 0000-0003-1910-0581
Keiji MurayamaDepartment of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Aichi, Japan.ORCID 0000-0002-6537-0120
Yusuke TakezawaCollege of Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Saitama, Japan.ORCID 0000-0003-1042-4870
Ryojun ToyodaDepartment of Chemistry, Graduate School of Science, Tohoku University, 6-3 Aramaki Aza-Aoba, Aoba-ku, Sendai 980-8578, Miyagi, Japan.ORCID 0000-0002-0168-0533
Akinori KuzuyaDepartment of Chemistry and Materials Engineering, Kansai University, 3-3-35 Yamate-cho, Suita 564-8680, Osaka, Japan.ORCID 0000-0003-0003-2996

Funding

Japan Science and Technology Agency JPMJFR2226Japan Science and Technology Agency JPMJPR22Q5Japan Science and Technology Agency JPMJPR23Q7Japan Science and Technology Agency JPMJSF23B6Japan Society for the Promotion of Science 20H05968Japan Society for the Promotion of Science 20H05969Japan Society for the Promotion of Science 20H05970Japan Society for the Promotion of Science 20H05972Japan Society for the Promotion of Science 22H05396Japan Society for the Promotion of Science 22K12239Japan Society for the Promotion of Science 22KF0356Japan Society for the Promotion of Science 23H00506Japan Society for the Promotion of Science 23H04399Japan Society for the Promotion of Science 23H04573Japan Society for the Promotion of Science 23K17868Japan Society for the Promotion of Science 24H01122Japan Society for the Promotion of Science 24H01699Japan Society for the Promotion of Science 24K01622Japan Society for the Promotion of Science 24K17666Japan Society for the Promotion of Science 25H01604Japan Society for the Promotion of Science 25K00080Japan Society for the Promotion of Science 25K01194Japan Society for the Promotion of Science 25K21817Japan Society for the Promotion of Science 25K22239
6 · The paper itself

Abstract

DNA and RNA, by focusing on their unique molecular properties, have transcended their role as carriers of genetic information in life and pioneered new application fields such as molecular robotics and molecular computing. However, as these technologies advance, the limitations inherent in natural nucleic acids and their ecosystems are increasingly becoming apparent as barriers to further application. To overcome these constraints, efforts to create artificial nucleic acids using chemical synthesis are underway and are now reaching a new stage of development. This paper proposes a concept of ultimate nucleic acid, "Omega Nucleic Acids (ΩNA)," as a thought experiment. We discuss the specifications required for this molecule, its implementable functions and approaches, and the construction of an ecosystem centered around ΩNA. By working backward from the characteristics of known natural and artificial nucleic acids, while envisioning next-generation artificial systems and applications in extreme environments, we aim to explore new approaches to nucleic acid chemistry and provide guidelines for constructing innovative artificial molecular systems.

Indexed as

DNANucleic AcidsRNAComputers, MolecularDNA NanostructuresNanotechnologyNucleic Acid ConformationRoboticsDNANucleic AcidsRNAchemical biologyDNADNA computingdrug deliverymolecular cyberneticsmolecular roboticsnucleic acidsstructural DNA nanotechnologyXNA

Identifiers

PMID41683500
PMCPMC12899278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.