Evidence map›Paper›PMID 41683494›Full record

ReviewMolecules (Basel, Switzerland)2026

Antimicrobial Peptide Nanoassemblies: Design, Response Mechanisms, and Biomedical Applications.

Tao Wang, Linbao Ji, Yucheng Zhang, Zhili Niu, Xiaoyi Jiang, Xingyao Wang, Qingtai Zhang, Yuting Zhang, Peng Tan, Yue Feng and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Nanosystems for delivery of indolicidin peptide.Frontiers in medical technology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tao WangResearch Center for Bio-Feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Linbao JiState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yucheng ZhangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Zhili NiuState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Xiaoyi JiangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Xingyao WangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Qingtai ZhangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0009-0006-0808-4503
Yuting ZhangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Peng TanState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yue FengState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Xi MaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-4562-9331
Zhihong SunResearch Center for Bio-Feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.

Funding

the 2115 Talent Development Program of China Agricultural University 1041-00109019the Beijing Rural Revitalization Project NY2401090324the National Key R&D Program of China 2022YFD1300404the National Key R&D Program of China 2023YFD1301103the National Key R&D Program of China 2024YFD1300403the National Natural Science Foundation of China U22A20514the National Natural Science Foundation of China U23A20232
6 · The paper itself

Abstract

The overuse of antibiotics has accelerated the evolution and mutation of drug-resistant bacteria, creating an urgent need for novel antimicrobial drugs and feed additives. Antimicrobial peptides, with their unique membrane-disrupting mechanism that resists the development of resistance, hold promise as antibiotic alternatives. To overcome the limitations of natural antimicrobial peptides-such as poor stability, susceptibility to protease degradation, and short in vivo half-lives-self-assembling peptide technology has emerged. This approach employs non-covalent interactions to orderly assemble monomeric peptides into stable, structured nanomaterials like nanofibers, nanotubes, and hydrogels. This paper outlines the molecular design principles and smart response mechanisms of antimicrobial peptide nanoassemblies, elucidates their core advantages over monomeric peptides, summarizes their application scenarios in anti-infection fields, and discusses limitations and future directions across various domains. It provides insights for future antimicrobial peptide design.

Indexed as

Anti-Infective AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesDrug DesignNanostructuresAnimalsAnti-Bacterial AgentsHumansNanofibersAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesAntimicrobial Peptidesanti-infectionantimicrobial peptide nanoassembliesintelligent responsemolecular designself-assembly

Identifiers

PMID41683494
PMCPMC12899442

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.