Evidence map›Paper›PMID 41683463›Full record

ArticleMolecules (Basel, Switzerland)2026

Down-Regulation of Acyloxyacyl Hydrolase Expression in Alzheimer's Disease Impairs LPS Detoxification and Contributes to Brain Pro-Inflammatory Signaling.

Yuhai Zhao, Nathan M Sharfman, Vivian R Jaber, Christopher M Taylor, Walter J Lukiw, Nicolas G Bazan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuhai ZhaoNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.ORCID 0009-0003-3014-2405
Nathan M SharfmanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.
Vivian R JaberNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.
Christopher M TaylorDepartment of Microbiology, Immunology & Parasitology, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.ORCID 0000-0002-7983-5275
Walter J LukiwNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.
Nicolas G BazanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.ORCID 0000-0002-9243-5444

Funding

NEI NIH HHS EY006311NIA NIH HHS AG038834NIA NIH HHS AG18031
6 · The paper itself

Abstract

Lipopolysaccharides (LPSs) are potent pro-inflammatory neurotoxins abundant in the gut microbiome and originate primarily from Gram-negative bacteria, such as

Indexed as

Alzheimer DiseaseBrainCarboxylic Ester HydrolasesDown-RegulationLipopolysaccharidesSignal TransductionHumansInflammationMicroRNAsacyloxyacyl hydrolaseCarboxylic Ester HydrolasesLipopolysaccharidesMicroRNAsacyloxyacyl hydrolase (AOAH)Alzheimer’s disease (AD)Bacteroides fragilishydrolasesinflammatory neurodegenerationlipaseslipopolysaccharide (LPS)microRNA-450b (miRNA-450b)neuroinflammation

Identifiers

PMID41683463
PMCPMC12898756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.