ArticleMolecules (Basel, Switzerland)2026
AX-2: A Promising Non-Hemolytic Protein of
Alain Cruz-Nolasco, Miguel Angel Peña-Rico, Sibel J Estrada-Escobedo, Angel A Ortela-Gregorio, Erick A Juarez-Arellano, Genaro Vázquez-Victorio, Angelica S Martinez-Ramirez, Michele Rorato Sagrillo, Roberto C Vianna Santos, Luz Camacho and 2 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Alain Cruz-NolascoDivisión de Estudios de Posgrado, Doctorado en Biotecnología, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, Tuxtepec 68301, Oaxaca, Mexico.ORCID 0009-0003-7973-9472 Miguel Angel Peña-RicoCentro de Investigaciones Científicas, Instituto de Biotecnología, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, Tuxtepec 68301, Oaxaca, Mexico.ORCID 0000-0001-8275-6044 Sibel J Estrada-EscobedoDivisión de Estudios de Posgrado, Maestría en Biotecnología, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, Tuxtepec 68301, Oaxaca, Mexico.
Angel A Ortela-GregorioDivisión de Estudios de Posgrado, Maestría en Biotecnología, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, Tuxtepec 68301, Oaxaca, Mexico.
Erick A Juarez-ArellanoCentro de Investigaciones Científicas, Instituto de Química Aplicada, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, Tuxtepec 68301, Oaxaca, Mexico.ORCID 0000-0003-4844-8317 Genaro Vázquez-VictorioFacultad de Ciencias, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.ORCID 0000-0002-2319-8772 Angelica S Martinez-RamirezCentro de Investigaciones Científicas, Instituto de Biotecnología, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, Tuxtepec 68301, Oaxaca, Mexico.ORCID 0000-0002-2474-4739 Michele Rorato SagrilloGraduate Program in Nanoscience, Franciscan University, Santa Maria 97010-032, RS, Brazil.ORCID 0000-0001-5659-159X Roberto C Vianna SantosOral Microbiology Laboratory, Universidade Federal de Santa Maria, Santa Maria 97065-060, RS, Brazil.ORCID 0000-0002-0533-3483 Luz CamachoLaboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Ciudad de Mexico 04530, Mexico.ORCID 0000-0002-9864-3738 Nayeli G Nieto-VelázquezDivisión de Investigación, Hospital Juárez de México, Ciudad de Mexico 07760, Mexico.ORCID 0000-0001-5354-9900 A Karin Navarro-MtzCentro de Investigaciones Científicas, Instituto de Biotecnología, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, Tuxtepec 68301, Oaxaca, Mexico.ORCID 0000-0003-4124-5533 Funding
Secretaría de Ciencia, Humanidades, Tecnología e Innovación CB-2015/258587 & BNT-2022-2/839539
6 · The paper itselfAbstract
Conventional cancer therapies often harm healthy tissues due to their poor specificity, resulting in significant side effects that diminish patients' quality of life. Parasporins, a group of non-hemolytic parasporal proteins produced by
Indexed as
Antineoplastic AgentsBacillus thuringiensisBacterial ProteinsBreast NeoplasmsEndotoxinsApoptosisCell SurvivalFemaleHumansMCF-7 CellsAntineoplastic AgentsBacterial ProteinsEndotoxinsparasporinanticancerapoptosisMCF-7oxidative stressparasporin ≈ 55 kDa
Identifiers
PMID41683452
PMCPMC12898861
What OpenQuestion holds
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LicenceCC BY
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