Evidence map›Paper›PMID 41683389›Full record

ArticleMolecules (Basel, Switzerland)2026

Polymyxin E-Modified Conjugated Polymer Nanoparticle for Photodynamic and Photothermal Combined Antimicrobial Therapy.

Qi Jiang, Yulu Hu, Huimin Ye, Xinyue Hu, Yue Yang, Minghui Yang, Fang Wang, Mengna Zhang, Lisheng Qian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qi JiangCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Yulu HuCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Huimin YeCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Xinyue HuCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Yue YangCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Minghui YangCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Fang WangCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Mengna ZhangCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Lisheng QianCollege of Biomedical and Health, Anhui Science and Technology University, Chuzhou 233100, China.

Funding

Anhui Provincial Department of Education 2024AH050328Anhui Science and Technology University S202310879205Anhui Science and Technology University S202310879206Anhui Science and Technology University S202410879201Anhui Science and Technology University S202410879202Anhui Science and Technology University SK202204
6 · The paper itself

Abstract

The irrational or excessive use of antibiotics causes the emergence of bacterial resistance, making antibiotics less effective or ineffective. As the number of resistant antibiotics increases, it is crucial to develop new strategies and innovative approaches to potentiate the efficacy of existing antibiotics. Prior to this, we discovered that some of the traditional antibiotics produce reactive oxygen species (ROS) under specific light exposure. In this paper, we report a multifunctional polymeric nanoparticle (F8IC NPs-PME) that combines targeted and photodynamic-photothermal therapy (PDT-PTT) in one device. The PME on the surface of F8IC enables the selective binding of F8IC NPs-PME to the surface of Gram-negative bacteria. In addition, PME and F8IC can generate ROS and photothermia under near-infrared light excitation, respectively. The results showed that the sterilization efficiency of F8IC NPs-PME at a concentration of 8 μg/mL was as high as 94.7% against kanamycin-resistant

Indexed as

Anti-Bacterial AgentsColistinNanoparticlesPhotochemotherapyPhotothermal TherapyPolymersEscherichia coliHumansInfrared RaysMicrobial Sensitivity TestsReactive Oxygen SpeciesAnti-Bacterial AgentsColistinPolymersReactive Oxygen Speciesconjugated polymer nanoparticlesphotodynamic antibacterialphotothermal antibacterialpolymyxin E

Identifiers

PMID41683389
PMCPMC12898741

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.