Coffee Cascara as a Source of Natural Antimicrobials: Chemical Characterization and Activity Against ESKAPE Pathogens.

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Antimicrobial Strategies in the Era of Resistance: It Is Too Early to Give Up Antibiotic Therapy.International journal of molecular sciences · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Merike VaherDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID 0000-0002-3818-1906

Olga BraginaDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID 0000-0001-5281-7758

Funding

Estonian Research Council TARISTU24-TK15Tallinn University of Technology SS22004

6 · The paper itself

Abstract

Coffee cascara is a byproduct of coffee production traditionally used for infusions and animal feed. In this study, aqueous extracts of cascara from three different sources (Cas1-Cas3) were analyzed for their polyphenol and flavonoid content, as well as the concentrations of key individual bioactive compounds including caffeine, trigonelline, chlorogenic acid, and protocatechuic acid. Among the tested samples, Cas1 exhibited the highest total polyphenol (802.2 mg GAE/L) and flavonoid (134.7 mg QE/L) contents. The antibacterial activity of these extracts and an artificial mixture of the four compounds were evaluated against ESKAPE pathogens. Cas1 exhibited the most promising antibacterial effect, with minimal bactericidal concentration (MBC) values as low as 0.03 mg/mL for

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsBiological ProductsCoffeaCoffeePlant ExtractsAcinetobacter baumanniiAlkaloidsFlavonoidsMicrobial Sensitivity TestsPolyphenolsPseudomonas aeruginosaStaphylococcus aureusAlkaloidsAnti-Bacterial AgentsAnti-Infective AgentsBiological ProductsCoffeeFlavonoidsPlant ExtractsPolyphenolsantibacterial activitycoffee cascaraESKAPE pathogensphytochemicalspolyphenols

Identifiers

PMID41683383

DOI10.3390/molecules31030403

PMCPMC12898695

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.