Evidence map›Paper›PMID 41683377›Full record

ArticleMolecules (Basel, Switzerland)2026

Anticancer Potential of Thieno[2,3-d]pyrimidine Derivatives in Oral Carcinoma Models.

Ivan Iliev, Aleksandrina Nesheva, Anelia Mavrova, Denitsa Yancheva, Aneliya Kostadinova, Severina Semkova, Albena Momchilova, Iana Tsoneva, Galya Staneva, Biliana Nikolova

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ivan IlievInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria.ORCID 0000-0002-2480-5116
Aleksandrina NeshevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.
Anelia MavrovaDepartment of Organic Chemistry, Faculty of Chemical Technologies, University of Chemical Technology and Metallurgy, S8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.ORCID 0000-0002-0455-4321
Denitsa YanchevaInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 9, 1113 Sofia, Bulgaria.ORCID 0000-0003-1580-9681
Aneliya KostadinovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.ORCID 0000-0002-8097-3608
Severina SemkovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.ORCID 0000-0002-2373-7713
Albena MomchilovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.
Iana TsonevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.ORCID 0000-0001-6908-6082
Galya StanevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.
Biliana NikolovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.ORCID 0000-0001-9742-9812

Funding

Bulgarian Ministry of Education and Science National Center for Biomedical Photonics D01-352/2023, part of the Bulgarian National Roadmap for Scientific Infrastructures 2020-2027.Bulgarian Ministry of Education and Science National Research Program "Young scientists and postdoctoral students-2", Module "Young sci-entists", for financial support on her project entitled "Interaction of conventional cytostatics with selected plant extracts on breast cancer models". to A.N.Bulgarian Ministry of Education and Science Scientific Infrastructure on Cell Technologies in Biomedicine (SICTB) D01-361/2023Bulgarian Science Fund KP-06-COST/30
6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) remains a major therapeutic challenge due to aggressive progression, high recurrence, and limited selectivity of current treatments. In this study, a series of seven 4-amino-2-substituted tetrahydrobenzothieno[2,3-d]pyrimidines were evaluated for their cytotoxic, antiproliferative, and mechanistic effects against oral cancer cell lines with different metastatic potential (HSC-3 and SCC-9), alongside non-tumorigenic keratinocytes (HaCaTs). Several compounds demonstrated selective anticancer activity, with Compounds

Indexed as

Antineoplastic AgentsCarcinoma, Squamous CellMouth NeoplasmsPyrimidinesApoptosisCell Line, TumorCell ProliferationHumansStructure-Activity RelationshipAntineoplastic AgentsPyrimidinesthieno(2,3-d)pyrimidineantiproliferative activityapoptosiscell cycle arrestcytoskeletondrug-likenessoral squamous cell carcinomathienopyrimidines

Identifiers

PMID41683377
PMCPMC12899554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.