Evidence map›Paper›PMID 41683369›Full record

ReviewNutrients2026

Cinnamon-Derived Phytonutrients as Modulators of Ion Channels and G Protein-Coupled Receptor Signaling in Metabolic Diseases.

Raymond Rubianto Tjandrawinata, Bayu Perkasa Rosari, Rony Abdi Syahputra, Reggie Surya, Fahrul Nurkolis

Abstract readReview
In one paragraph

Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Cinnamon and Derivatives as Modulators of Toll-like Receptors.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Evaluation of potential ofFrontiers in pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raymond Rubianto TjandrawinataSchool of Bioscience, Innovation and Technology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia.ORCID 0000-0003-0461-9874
Bayu Perkasa RosariDepartment of Anatomical Pathology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta 14440, Indonesia.ORCID 0009-0000-0381-1480
Rony Abdi SyahputraDepartment of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.ORCID 0000-0003-2016-0151
Reggie SuryaDepartment of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta 11480, Indonesia.
Fahrul NurkolisMaster of Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.ORCID 0000-0003-2151-0854

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic diseases such as type 2 diabetes and obesity are increasingly recognized as disorders of dysregulated cellular communication rather than solely enzymatic or transcriptional dysfunction. While conventional therapies primarily target metabolic enzymes and nuclear receptors, growing evidence highlights ion channels and G protein-coupled receptors (GPCRs) at the cell membrane as critical upstream regulators of glucose homeostasis, energy expenditure, and inflammation. Cinnamon (

Indexed as

Cinnamomum zeylanicumIon ChannelsMetabolic DiseasesPhytochemicalsReceptors, G-Protein-CoupledSignal TransductionAnimalsEnergy MetabolismHumansInsulin SecretionIon ChannelsPhytochemicalsReceptors, G-Protein-Coupledcalcium signalingcinnamonenergy metabolismGPCR signalinginsulin secretionion channelsmetabolic diseasesnutraceuticalsprecision nutritionTRP channels

Identifiers

PMID41683369
PMCPMC12899492

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.