Trial reportNutrients2026
Hyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial.
Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hypnotic Effects ofNutrients · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND/
objectivesSleep is fundamental to physical and mental health, yet many individuals experience impaired sleep quality. Although pharmacological interventions are available, they are associated with risks of dependency and adverse effects, underscoring the urgent need for safer, food-based alternatives. Blueberry leaves, rich in hyperoside, are suggested to influence sleep through serotonergic and melatonergic pathways; however, while their potential to help maintain sleep quality has been noted, the sleep-enhancing effects of fermented blueberry leaf tea have not yet been demonstrated. This present randomized, double-blind, placebo-controlled trial evaluated the sleep-enhancing effects of fermented blueberry leaf tea on sleep quality.
methodsFifty adults (aged 20-69 years) reporting poor sleep were randomly assigned to consume either fermented blueberry leaf tea (n = 25) or placebo tea (n = 25) three times daily for two weeks. Objective sleep parameters-sleep efficiency, wake after sleep onset (WASO), sleep latency, and total sleep time-were assessed using actigraphy, while subjective sleep quality was evaluated using the Oguri-Shirakawa-Azumi Sleep Inventory MA (OSA-MA) version questionnaire.
resultsIn the per-protocol analysis (active: n = 22; placebo: n = 20), the active group exhibited significant improvements in sleep efficiency and WASO compared with the placebo (
conclusionsThese findings demonstrate that fermented blueberry leaf tea may enhance sleep continuity within two weeks, particularly among individuals with fragmented sleep, and support the potential role of functional foods in sleep health strategies.
trial registrationUniversity Hospital Medical Information Network (UMIN), UMIN000055879; registered on 21 October 2024.
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