Evidence map›Paper›PMID 41682828›Full record

ReviewJournal of clinical medicine2026

Primary Sclerosing Cholangitis: Diagnosis, Management, and Clinical Challenges.

Sofia Svensson Di Giorgio, Chiara Maria Scandavini, Antonio Molinaro, Urban Arnelo, Roberto Valente

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sofia Svensson Di GiorgioDepartment of Diagnostics and Intervention, Surgery, Umeå University, 901 87 Umeå, Sweden.
Chiara Maria ScandaviniDepartment of Diagnostics and Intervention, Surgery, Umeå University, 901 87 Umeå, Sweden.
Antonio MolinaroDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, 405 30 Gothenburg, Sweden.
Urban ArneloDepartment of Diagnostics and Intervention, Surgery, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0002-1843-5673
Roberto ValenteDepartment of Diagnostics and Intervention, Surgery, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0002-6785-2326

Funding

Bengt Ihre fellowship research grant (RV) NACancerforskningsfonden i Norrland/Lions' cancer research foundation, Umeå University LP22-2301Cancerforskningsfonden i Norrland/Lions' cancer research foundation, Umeå University (RV) AMP 21-1058Cancerforskningsfonden i Norrland/Lions' cancer research foundation, Umeå University (RV) LP 24-2376Cancer och allergi fonden (UA) 10384City Council of Västerbotten (RV) RV-970141City Council of Västerbotten (RV) RV-980274City Council of Västerbotten (RV) RV-982725IngaBritt och Arne Lundbergs Forskningsstiftelse (RV) NAMag-tarmfonden (AM) NASvenska Läkaresallskapet (RV) SLS-961919Svenska Läkaresallskapet (RV) SLS-961923Swedish Cancer Society Cancerfonden (UA) 19 0513 Fk 01 H
6 · The paper itself

Abstract

Primary sclerosing cholangitis is a rare, chronic, inflammatory disease of the biliary tree that leads to progressive ductal obliteration, hepatic dysfunction, and ultimately liver cirrhosis. Most patients eventually require liver transplantation or develop serious complications, the most severe being end-stage liver disease and cholangiocarcinoma. The global prevalence of PSC is rising and has been reported to reach up to 31.7 cases per 100,000 individuals, representing a significant challenge in both diagnosis and management. In this review, we aim to provide a clinically oriented overview of the diagnosis and management of PSC. Furthermore, we seek to highlight key challenges and areas of uncertainty that clinicians encounter in the diagnosis and treatment of patients with this complex disease.

Indexed as

cholangiocarcinomaclinical challengesdiagnosisPSCsclerosing cholangitis

Identifiers

PMID41682828
PMCPMC12897808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.