Evidence map›Paper›PMID 41682343›Full record

ArticleSensors (Basel, Switzerland)2026

Interpreting Modulation Transfer Function in Endoscopic Imaging: Spatial-Frequency Conversion Across Imaging Spaces and the Digital Image Domain with Case Studies.

Quanzeng Wang

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Quanzeng WangCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.ORCID 0000-0002-0557-7058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoscopes are widely used in medicine, making objective evaluation of imaging performance essential for device development and quality assurance. Image resolution is commonly characterized by the modulation transfer function (MTF); however, its interpretation depends critically on how spatial frequency is defined and reported. Because spatial frequency is directly tied to sampling, it can be expressed in different units across the imaging chain, including the object plane, image sensor plane, and digital image domain. Inconsistent conversion between these spaces and domains can mislead comparisons and even alter the apparent ranking of regions of interest (ROIs) or imaging systems. This work presents a systematic analysis of spatial-frequency relationships along the endoscopic imaging chain and provides a practical conversion and interpretation workflow for MTF analysis. The framework accounts for sensor sampling, in-camera processing, resampling or scaling, and geometric distortion. Because geometric distortion introduces position-dependent sampling across the field of view, ROI-specific local-magnification measurements are incorporated to convert measured MTFs to a consistent object space spatial-frequency axis. Two case studies illustrate the implications. First, an off-axis ROI may appear to outperform the image center when MTF is expressed in digital image domain cycles per pixel, but this conclusion reverses after conversion to object space cycles per millimeter using local magnification. Second, resampled image outputs can yield inflated MTF curves unless scaling differences between formats are explicitly incorporated into the spatial-frequency axis. Overall, the proposed conversion and reporting workflow enables consistent and physically meaningful MTF comparison across devices, ROIs, and acquisition configurations when geometric distortion, sampling, or resampling differs, clarifying how optics, sensor characteristics, and image processing jointly determine reported MTF results.

Indexed as

angular spatial frequencydigital image domaingeometric distortionimage dimensionsimage sensor planeimage spaceimaging chainISO 12233ISO 8600-5local magnificationmodulation transfer functionMTFobject planeobject spacepicture heightpixel pitchpixel resolutionresamplescaling factorslanted edgespatial frequencyspatial frequency response (SFR)spatial resolutionvideo endoscope

Identifiers

PMID41682343
PMCPMC12899431

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.