Evidence map›Paper›PMID 41682225›Full record

ReviewHealthcare (Basel, Switzerland)2026

The Psychological Impact of In Vitro Fertilization (IVF): A Gender Systematic Review.

Maria Grammenou, Vasiliki Michou, Aikaterini Itziou, Arsenios Tsiotsias, Panagiotis Eskitzis

Abstract readReview
In one paragraph

Review in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria GrammenouDepartment of Midwifery, School of Healthcare Sciences, University of Western Macedonia, Keptse, 50200 Ptolemaida, Greece.
Vasiliki MichouDepartment of Midwifery, School of Healthcare Sciences, University of Western Macedonia, Keptse, 50200 Ptolemaida, Greece.ORCID 0000-0002-7097-2927
Aikaterini ItziouDepartment of Midwifery, School of Healthcare Sciences, University of Western Macedonia, Keptse, 50200 Ptolemaida, Greece.ORCID 0000-0001-9652-2652
Arsenios TsiotsiasDepartment of Midwifery, School of Healthcare Sciences, University of Western Macedonia, Keptse, 50200 Ptolemaida, Greece.ORCID 0000-0002-8666-8380
Panagiotis EskitzisDepartment of Midwifery, School of Healthcare Sciences, University of Western Macedonia, Keptse, 50200 Ptolemaida, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn Vitro Fertilization (IVF) has revolutionized reproductive medicine, offering hope to individuals and couples facing infertility. However, the psychological impact of IVF varies significantly based on gender, necessitating a systematic review of the existing literature. This review explores the emotional effects of IVF on both men and women, highlighting gender-specific psychological responses throughout the treatment process.

methodsA systematic literature search using various databases (such as PubMed) was made. Studies published in English from the years 2000 to 2023 were included in the review.

resultsA total of 47 studies examined the psychological impact of IVF on both women and men, covering the IVF programming period, the initial stages of IVF treatment, and subsequent stages, as well as the long-term psychological distress effects of IVF in both genders. Both female and male infertile patients are dealing with anxiety, depression and low quality of life. However, women were found to experience higher levels of psychological distress, including increased anxiety and depression symptoms, compared to men at nearly all stages of IVF treatment.

conclusionsUnderstanding these gender-specific differences is crucial for developing targeted psychological support interventions to improve mental well-being during IVF treatments.

Indexed as

gender differencesinfertilityin vitro fertilizationmental healthpsychological impact

Identifiers

PMID41682225
PMCPMC12897396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.