ArticlePolymers2026
Silk Fibroin Hydrogel Microneedles Loaded with Recombinant Human Nerve Growth Factor for Corneal Tissue Engineering.
Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dissolving microneedle patches loaded with resveratrol albumin nanoclusters for corneal anti-angiogenic therapy.International journal of pharmaceutics: X · 2026Article
- Recent Advances in Extended Ocular Drug Delivery for the Ocular Surface.Molecules (Basel, Switzerland) · 2026Review
- Innovative microneedle-integrated hydrogels: a promising strategy for diabetic foot ulcer management.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Corneal nerves are essential for maintaining the functional integrity of the ocular surface. Damage to corneal nerves can lead to corneal issues and impaired vision. Current treatments for corneal nerve damage are inadequate, thus highlighting the need for innovative therapeutic approaches. In this study, we present a hydrogel microneedle system designed to facilitate the sustained release of recombinant human nerve growth factor (rhNGF). The microneedle features a tip composed of glycidyl methacrylate modified silk fibroin (SFMA) loaded with rhNGF, photopolymerized for structural integrity, while its base is formed using silk fibroin (SF). This design allows the microneedles to penetrate the corneal epithelium and deliver rhNGF to the sub-epithelial layer. The crosslinking process not only provides the mechanical strength required for microneedle penetration but also enables sustained drug release. The proposed rhNGF-loaded SF hydrogel microneedle provides a platform for drug delivery, serving as a novel therapeutic option for corneal tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.