Evidence map›Paper›PMID 41681979›Full record

ArticleCancers2026

Phase II Study of Pegvorhyaluronidase Alfa (PEGPH20) and Pembrolizumab for Patients with Hyaluronan-High, Pretreated Metastatic Pancreatic Ductal Adenocarcinoma: PCRT16-001.

Elena Gabriela Chiorean, Sheela R Damle, David B Zhen, Martin Whittle, Ben George, Howard Hochster, Andrew L Coveler, Andrew Hendifar, Tomislav Dragovich, Rachael A Safyan and 9 more

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Elena Gabriela ChioreanUniversity of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0003-3306-9592
Sheela R DamleUniversity of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0001-6688-0950
David B ZhenUniversity of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0003-3375-5912
Martin WhittleFred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Ben GeorgeMedical College of Wisconsin, Milwaukee, WI 53226, USA.
Howard HochsterRutgers Cancer Institute, New Brunswick, NJ 08903, USA.
Andrew L CovelerUniversity of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0003-1710-5637
Andrew HendifarCedar-Sinai Medical Center, Los Angeles, CA 90048, USA.
Tomislav DragovichBaptist MD Anderson Cancer Center, Jacksonville, FL 32207, USA.
Rachael A SafyanUniversity of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-0181-6007
Gentry T KingUniversity of Washington School of Medicine, Seattle, WA 98195, USA.
William P HarrisUniversity of Washington School of Medicine, Seattle, WA 98195, USA.
Barbara DionMedical College of Wisconsin, Milwaukee, WI 53226, USA.
Amy Stoll D'AsticeCancer Research and Biostatistics, Seattle, WA 98109, USA.
Arthur LeeCancer Research and Biostatistics, Seattle, WA 98109, USA.
Shelley ThorsenFred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Sita KugelFred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Adam RosenthalCancer Research and Biostatistics, Seattle, WA 98109, USA.
Sunil HingoraniFred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Funding

OVERCOMING STROMAL BARRIERS TO THERAPEUTICS IN PANCREAS CANCERR01CA161112 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sunil R Hingorani · 2011 to 2026
$7.6M
Fred Hutchinson Cancer Center Support Grant 5P30CA015704-39Halozyme Therapeutics (United States) HALO 109-9902Merck Pharmaceuticals MISP 53041NCI NIH HHS R01 CA161112
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

hyaluronidasepancreatic adenocarcinomaPEGPH20pembrolizumabstromatumor immune microenvironment

Identifiers

PMID41681979
PMCPMC12896646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.