ReviewCancers2026
Dermoscopy of Subungual Squamous Cell Carcinoma: A Systematic Review.
Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSubungual squamous cell carcinoma is a rare malignancy of the nail unit that is frequently misdiagnosed as benign nail disease, leading to prolonged diagnostic delays and sometimes invasive spread.
objectiveTo synthesize the dermoscopic features of histologically confirmed subungual squamous cell carcinoma and to compare patterns between invasive and in situ disease.
methodsWe performed a systematic review and meta-analysis (PROSPERO CRD42023470387) following PRISMA and MOOSE guidance. PubMed, Scopus and Cochrane CENTRAL were searched. Extracted data included study design, lesion counts, histologic subtype and specific dermoscopic signs. Random-effects meta-analysis (DerSimonian-Laird with Freeman-Tukey transformation) produced pooled prevalences with 95% confidence intervals. Between-study heterogeneity was assessed with Cochran's Q and
resultsTwenty studies comprising 121 lesions (96 invasive, 25 in situ) were included. In invasive lesions, the most common dermoscopic findings were subungual hyperkeratosis (pooled prevalence 89%; 95% CI 78-97;
conclusionsDermoscopy reliably identifies features, particularly hyperkeratosis, onycholysis, irregular margins and hemorrhagic spots, that are common in invasive subungual squamous cell carcinoma; in situ disease more commonly presents with pigmentary changes. Recognition of these signs should lower the threshold for biopsy of suspicious single-digit nail lesions and may facilitate earlier diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.