ArticleCancers2026
Safety and Feasibility Colorectal Anastomosis Protocol Implementation: Results from the CASPI Single-Arm Pilot Study.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
BACKGROUND/
objectivesAnastomotic leakage (AL) is a major complication of colorectal surgery. Despite multiple identified risk factors, no single strategy has proven fully effective in preventing AL. This single-arm pilot study aims to evaluate the feasibility, safety, and adherence of a multimodal colorectal anastomosis assessment protocol (CASPI) in patients undergoing surgery for colorectal cancer.
methodsThis prospective descriptive interventional single-arm pilot study included patients diagnosed with colorectal cancer who underwent surgical resection. The CASPI protocol consists of five steps: (1) indocyanine green (ICG) perfusion assessment, (2) doughnut integrity checking, (3) air leak testing, (4) intraoperative flexible endoscopy, and (5) postoperative flexible sigmoidoscopy.
resultsA total of 34 patients were included. The median age was 63.5 years, and the median BMI was 27.7 kg/m
conclusionsImplementation of the CASPI protocol in colorectal surgery demonstrated excellent feasibility, high adherence, and strong safety. These findings support its further evaluation in larger, controlled studies designed to assess clinical effectiveness in the incidence of anastomotic complications.
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