Evidence map›Paper›PMID 41681847›Full record

ArticleCancers2026

Lipidemic Profile of Patients with Non-Small Cell Lung Cancer and Its Association with Driver Mutations: A Tertiary Center Retrospective Study.

Maria Lagadinou, Dimitrios Efthymiou, Fotios Sampsonas, Prokopis Karidis, Ioanna Marlafeka, Eirini Adamopoulou, Christos Michailides, Pinelopi Bosgana, Ourania Papaioannou, Emmanouil Psarros and 6 more

Abstract read
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In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maria LagadinouDepartment of Internal Medicine, Medical School, University Hospital of Patras, 265 04 Patras, Greece.
Dimitrios EfthymiouDepartment of Internal Medicine, Medical School, University Hospital of Patras, 265 04 Patras, Greece.
Fotios SampsonasRespiratory Medicine Department, Medical School, University of Patras, 265 04 Patras, Greece.ORCID 0000-0002-7796-2959
Prokopis KaridisDepartment of Internal Medicine, Medical School, University Hospital of Patras, 265 04 Patras, Greece.
Ioanna MarlafekaDepartment of Internal Medicine, Medical School, University Hospital of Patras, 265 04 Patras, Greece.
Eirini AdamopoulouDepartment of Internal Medicine, Medical School, University Hospital of Patras, 265 04 Patras, Greece.
Christos MichailidesDepartment of Internal Medicine, Medical School, University Hospital of Patras, 265 04 Patras, Greece.ORCID 0000-0003-1712-9815
Pinelopi BosganaDepartment of Pathology, Agios Andreas Hospital of Patras, 265 04 Patras, Greece.
Ourania PapaioannouRespiratory Medicine Department, Medical School, University of Patras, 265 04 Patras, Greece.ORCID 0000-0003-3889-679X
Emmanouil PsarrosRespiratory Medicine Department, Medical School, University of Patras, 265 04 Patras, Greece.
Panagiota TsiriRespiratory Medicine Department, Medical School, University of Patras, 265 04 Patras, Greece.ORCID 0009-0000-3894-0231
Vasilina SotiropoulouRespiratory Medicine Department, Medical School, University of Patras, 265 04 Patras, Greece.
Matthaios KatsarasRespiratory Medicine Department, Medical School, University of Patras, 265 04 Patras, Greece.
Vasiliki TzelepiDepartment of Pathology, University Hospital of Patras, 265 04 Patras, Greece.ORCID 0000-0002-9613-4681
Argyrios TzouvelekisRespiratory Medicine Department, Medical School, University of Patras, 265 04 Patras, Greece.
Markos MarangosDepartment of Internal Medicine, Medical School, University Hospital of Patras, 265 04 Patras, Greece.ORCID 0000-0001-5030-2398

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAltered lipid metabolism has been reported in several malignancies, but its clinical relevance in non-small cell lung cancer (NSCLC) remains uncertain. This study aimed to compare serum lipid parameters between NSCLC patients and healthy controls and to explore their association with histological subtype and selected driver mutations.

methodsWe retrospectively analyzed serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) in patients diagnosed with adenocarcinoma or squamous cell carcinoma from 2021 to 2024, alongside a control group of 100 healthy individuals. Statistical comparisons were performed using appropriate parametric or nonparametric tests after normality assessment (Shapiro-Wilk), and

resultsA total of 160 NSCLC patients were included. Most were male (75.5%) and current or former smokers (96.1%), with a mean age of 70.4 ± 10.3 years. Squamous cell carcinoma was the predominant subtype (64.4%). Hypocholesterolemia was observed in 59.9% of patients, while hypercholesterolemia was less frequent (40.1%). Compared with controls, patients had significantly lower HDL levels (

conclusionsIn this retrospective, real-world cohort, only HDL levels demonstrated a robust difference between NSCLC patients and controls. Observed associations should be interpreted cautiously due to potential confounding factors and incomplete clinical data inherent to retrospective analyses. Prospective studies are needed to clarify whether lipid alterations play a biological or prognostic role in NSCLC.

Indexed as

adenocarcinomalung cancersquamous cell carcinomatotal cholesteroltriglycerides

Identifiers

PMID41681847
PMCPMC12896490

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