ArticleCancers2026
Naloxegol, an Oral Peripherally Acting Opioid Receptor Antagonist, Administered Concurrently with First-Line Systemic Therapy for Advanced Lung Adenocarcinoma (Alliance A221504): A Feasibility and Safety Study.
Pankaj Gupta, Kalpna Gupta, Travis Dockter, Elizabeth Harlos, Selina Chow, Niveditha Subbiah, Kathryn J Ruddy, Lyudmila Bazhenova, Shelby Terstriep, Chao H Huang and 3 more
Abstract read
In one paragraphArticle in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Kalpna GuptaDepartment of Medicine, University of California Irvine, Orange, CA 92868, USA.
Travis DockterAlliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN 55905, USA.
Elizabeth HarlosAlliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN 55905, USA.
Selina ChowAlliance Protocol Operations Office, University of Chicago, Chicago, IL 60606, USA.
Niveditha SubbiahAlliance Protocol Operations Office, University of Chicago, Chicago, IL 60606, USA.ORCID 0009-0006-0049-0902 Kathryn J RuddyDepartment of Medical Oncology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-6298-332X Lyudmila BazhenovaDepartment of Medicine, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0001-8764-4359 Shelby TerstriepSanford Roger Maris Cancer Center, Fargo, ND 58102, USA.
Chao H HuangVA Medical Center, Kansas City, MI 64128, USA.
Everett E VokesDepartments of Medicine and Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.
Charles L LoprinziDepartment of Medical Oncology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-8044-5752 Funding
SWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1MCollaborations and NCORP Collective ManagementUG1CA189823 · NCI · MAYO CLINIC ROCHESTER · PI Evanthia Galanis, Olwen Hahn · 2014 to 2026
$120.6MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MUG1 - NCTN (Network Lead)UG1CA233327 · NCI · UNIVERSITY OF CHICAGO · PI STEVEN J CHMURA, HEDY L KINDLER · 2019 to 2026
$4.4MALLIANCE Foundation (United States) Not applicableAstraZeneca (United States) Not applicableNCI NIH HHS U10 CA180888NCI NIH HHS U10CA180888NCI NIH HHS UG1 CA189823NCI NIH HHS UG1CA189823NCI NIH HHS UG1 CA189974NCI NIH HHS UG1 CA233327NCI NIH HHS UG1CA233327
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Indexed as
antineoplastic agentsconstipationlung neoplasmsnarcotic antagonistsopioidpainquality of liferandomized controlled trialreceptors
Identifiers
PMID41681846
PMCPMC12896856
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