Evidence map›Paper›PMID 41681843›Full record

ArticleCancers2026

Dual Targeting of IDH2 and the Ubiquitin-Proteasome System Reveals a Functional Vulnerability in Breast Cancer Models.

Nariman Gharari, Elisabetta Mereu, Beatrice Luciano, Bahareh Heidari, Sylvie Mader, Roberto Piva

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nariman GharariDepartment of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.ORCID 0009-0004-0510-6266
Elisabetta MereuDepartment of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.
Beatrice LucianoDepartment of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.ORCID 0009-0004-9770-3374
Bahareh HeidariInstitute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC H3C 3J7, Canada.ORCID 0009-0000-8823-0350
Sylvie MaderInstitute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC H3C 3J7, Canada.ORCID 0000-0002-6423-627X
Roberto PivaDepartment of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-2273-3470

Funding

Associazione Italiana per la Ricerca sul Cancro (AIRC) Investigator Grant-21585Natural Sciences and Engineering Research Council of Canada (NSERC) 110_2025_2026_Q1_2918
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

breast cancercombinatorial treatmentfunctional synergyIDH2 inhibitionproteasome inhibitors

Identifiers

PMID41681843
PMCPMC12896526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.