Evidence map›Paper›PMID 41681452›Full record

ArticleAnimals : an open access journal from MDPI2026

Development of a Mucosal Immune-Enhancing Oral Vaccine Candidate Against Porcine Epidemic Diarrhea Virus Using

Yijie Yang, Ling Sui, Yuliang Zhao, Jiaxuan Li, Fengsai Li, Wen Cui, Yanping Jiang, Lijie Tang, Dianzhong Zheng, Xiaona Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yijie YangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Ling SuiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Yuliang ZhaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Jiaxuan LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Fengsai LiHebei Key Laboratory of Preventive Veterinary Medicine, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China.
Wen CuiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Yanping JiangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Lijie TangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Dianzhong ZhengInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150030, China.
Xiaona WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.

Funding

National Natural Science Foundation of China 32573406Scientific Research Fund of the Hebei Normal Unixersity of Science and Technology 2023YB004
6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) is a highly infectious virus that leads to severe diarrhea and high death rates in neonatal piglets. Because PEDV primarily infects the intestinal mucosa, the induction of effective mucosal immunity through oral vaccination represents a promising strategy for disease prevention. In this study, a recombinant

Indexed as

dendritic cell-targeting peptideLactobacillus paracaseiLTBM cell-targeting peptideoral vaccinePEDV S1 protein

Identifiers

PMID41681452
PMCPMC12896885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.