Evidence map›Paper›PMID 41681386›Full record

ArticleAnimals : an open access journal from MDPI2026

Ptch2 Deficiency Triggers Lipoma Formation and Adipogenic Transcriptome Reprogramming in Nile tilapia (

Changle Zhao, Xiang Liu, Xi Peng, Yongxun Chen, Shijian Peng, Lei Liu, Deshou Wang, Jing Wei

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Changle ZhaoIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Chongqing Technology Innovation Center of Breeding, School of Life Sciences, Southwest University, Chongqing 400715, China.
Xiang LiuIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Chongqing Technology Innovation Center of Breeding, School of Life Sciences, Southwest University, Chongqing 400715, China.
Xi PengSichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengluo Avenue, Chengdu 610106, China.
Yongxun ChenIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Chongqing Technology Innovation Center of Breeding, School of Life Sciences, Southwest University, Chongqing 400715, China.
Shijian PengIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Chongqing Technology Innovation Center of Breeding, School of Life Sciences, Southwest University, Chongqing 400715, China.
Lei LiuIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Chongqing Technology Innovation Center of Breeding, School of Life Sciences, Southwest University, Chongqing 400715, China.
Deshou WangIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Chongqing Technology Innovation Center of Breeding, School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0000-0002-4967-524X
Jing WeiIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Chongqing Technology Innovation Center of Breeding, School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0000-0003-1062-6691

Funding

National Key Research and Development Program of China No. 2022YFD1201600The National Natural Science Foundation of China No. 32573507, 32172969The Southwest University of Graduate Student Research Innovation Project SWUS25088
6 · The paper itself

Abstract

The Hedgehog (Hh) signaling pathway is a key regulator of adipogenesis and lipid metabolism. However, the specific role of its receptor, Patched2 (Ptch2), in these processes remains unclear. Here, using a CRISPR/Cas9-mediated

Indexed as

lipid metabolismlipomaNile tilapiaPatched2 (Ptch2)transcriptome

Identifiers

PMID41681386
PMCPMC12896722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.