ArticleImplementation science communications2026
Collection of implementation-related data in pragmatic clinical trials: a cross-sectional study from the NIH Pragmatic Trials Collaboratory.
Katy E Trinkley, Shruti Gohil, Stacie A Salsbury, Diana J Burgess, Ardith Z Doorenbos, Brian S Mittman, Wynne E Norton, Hayden B Bosworth, Karen L Staman, Devon Check
Abstract read
In one paragraphArticle in Implementation science communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Shruti GohilUniversity of California Irvine School of Medicine, Irvine, CA, USA.
Stacie A SalsburyPalmer Center for Chiropractic Research, Palmer College of Chiropractic, Davenport, IA, USA.
Diana J BurgessCenter for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, Minneapolis, MN, USA.
Ardith Z DoorenbosUniversity of Illinois, College of Nursing, Chicago, IL, USA.
Brian S MittmanKaiser Permanente Southern California, Pasadena, CA, USA.
Wynne E NortonDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Hayden B BosworthDuke University Department of Population Health Sciences, Durham, NC, USA.
Karen L StamanDuke Clinical Research Institute, Durham, NC, USA.
Devon CheckUniversity of Michigan Medical School, Ann Arbor, MI, USA.
Funding
NIH Health Care Systems Research Collaboratory-Coordinating Center (U24)U24AT009676 · NCCIH · DUKE UNIVERSITY · PI LESLEY H CURTIS, Adrian Hernandez · 2017 to 2026
$21.5MHybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease PainUH3AT011265 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOORENBOS, ARDITH Z, EZENWA, MIRIAM OMELEBELE · 2021 to 2024
$6.4MPersonalized Patient data and behavioral nudges to improve adherence to chronic cardiovascular medicationsUH3HL144163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALLEN, LARRY ALEXANDER, BULL, SHEANA S · 2019 to 2022
$5.7MRemote Tai Chi for Knee Osteoarthritis: an Embedded Pragmatic TrialUH3AT012413 · NCCIH · TUFTS MEDICAL CENTER · PI Helen Lavretsky, Eric J Roseen · 2024 to 2026
$5.6MReaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP-WH)UH3NR020929 · NINR · CENTER FOR VETERANS RESEARCH AND EDUCATION · PI BURGESS, DIANA J, EVANS, RONI L. · 2025 to 2025
$3.6M2/2: IMPACt-LBP DCCU24AT011189 · NCCIH · DUKE UNIVERSITY · PI CHAKRABORTY, HRISHIKESH · 2021 to 2025
$3.5MMentoring and Research in Translational Science of Integrative MedicineK24AT009198 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Helen Lavretsky · 2016 to 2026
$1.4MReaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP-WH)UG3NR020929 · NINR · CENTER FOR VETERANS RESEARCH AND EDUCATION · PI BURGESS, DIANA J, EVANS, RONI L. · 2023 to 2023
$1.3M1/2 IMPACt-LBP CCCUG3AT011187 · NCCIH · DUKE UNIVERSITY · PI GOERTZ, CHRISTINE MARIE, GOODE, ADAM · 2021 to 2021
$958kRemote Tai Chi for Knee Osteoarthritis: an Embedded Pragmatic TrialUG3AT012413 · NCCIH · TUFTS MEDICAL CENTER · PI LAVRETSKY, HELEN, ROSEEN, ERIC J · 2023 to 2023
$912kPersonalizing Clinical Decision Support for Heart Failure Treatment to Clinicians' NeedsK23HL161352 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Katy E Trinkley · 2022 to 2026
$869kHybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease PainUG3AT011265 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOORENBOS, ARDITH Z, EZENWA, MIRIAM OMELEBELE · 2020 to 2020
$827kDivision of Intramural Research, National Institute of Allergy and Infectious Diseases U01AI153005NCCIH NIH HHS K24 AT009198NCCIH NIH HHS U24 AT009676NCCIH NIH HHS U24AT009676NCCIH NIH HHS U24 AT011189NCCIH NIH HHS U24AT011189NCCIH NIH HHS UG3 AT011187NCCIH NIH HHS UG3AT011187NCCIH NIH HHS UG3 AT011265NCCIH NIH HHS UG3AT011265NCCIH NIH HHS UG3 AT012413NCCIH NIH HHS UG3AT012413NCCIH NIH HHS UH3 AT011265NCCIH NIH HHS UH3AT011265NCCIH NIH HHS UH3 AT012413NCCIH NIH HHS UH3AT012413NHLBI Division of Intramural Research UG3HL144163NHLBI Division of Intramural Research UH3HL144163NHLBI NIH HHS K23 HL161352NHLBI NIH HHS UG3 HL144163NHLBI NIH HHS UH3 HL144163NINR NIH HHS UG3 NR020929NINR NIH HHS UG3NR020929NINR NIH HHS UH3 NR020929
6 · The paper itselfAbstract
backgroundEmbedded pragmatic clinical trials (ePCTs) are conducted as part of routine care, which provides researchers and health systems multiple opportunities to study implementation processes and outcomes.
methodsWe conducted a cross-sectional survey of 32 ePCTs associated with the NIH Pragmatic Trials Collaboratory to assess the implementation-related outcomes that were measured or were planned to be measured, including reach (number and percent of eligible patients who participate in an intervention and the representativeness of those patients), patient engagement in or adherence to the intervention, adoption (number and percent of eligible organizations or clinicians that decide to take up or use an intervention), fidelity (clinician's delivery of an intervention as intended), adaptations (changes or modifications to an intervention), sustainability (potential for an intervention to be maintained or institutionalized after a trial concludes), sustainment (actual maintenance or institutionalization of an intervention after a trial concludes), and costs. The trials represented different phases of progress (planned, ongoing, or completed).
results91% of study teams completed the survey, and most (86%) reported measuring reach. The total number of teams measuring other outcomes was 76% for adherence, 45% for clinician adoption, 93% for fidelity, 69% for adaptations, 24% for sustainability, 38% for sustainment, and 31% for costs.
conclusionThere is an opportunity for growth in measuring clinician adoption of the intervention, sustainability, sustainment, and associated costs. Measurement of these constructs in future ePCTs could result in development of improved implementation strategies to increase the likelihood of effective implementation leading to equitable, sustainable, and scalable improvement in practice.
Indexed as
CostsImplementation sciencePragmatic clinical trialSustainability
Identifiers
PMID41680937
PMCPMC13005506
What OpenQuestion holds
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LicenceCC BY
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