ArticleInternational breastfeeding journal2026
Exclusive breastfeeding and infantile colic: a cohort study.
Article in International breastfeeding journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundInfant colic or excessive crying in early life is a common symptom without a clear understanding of etiology and management. Breastfeeding has both short and long-term health benefits for mothers and children.
methodsThis study was a secondary analysis of a prospective intervention trial on breastfeeding promotion in Vietnam. A total of 856 mother-infant dyads were included to investigate the association between sources of nutrition and infant colic. Data on the exclusive breastfeeding were collected twice in 1-week and 4-weeks after delivery. Colic cases were defined using Rome IV criteria.
resultsThe prevalence of colic was 17.2% (95%CI: 14.6 to 19.7%) among infant 3–21 weeks of age, peaked at 7–9 weeks (23.7%, 95%CI: 17.4 to 30.0%), and almost dismissed after 12 weeks (3.6%, 95%CI: 0.08 to 7.2%). In multivariable analyses, compared with mixed feeding, infants under 10 weeks who had exclusive breastfeeding since birth were significantly less likely to have colic (aOR = 0.33; CI: 0.18 to 0.60) after controlling for maternal age, educational level, pre-pregnancy body mass index, parity, mode of delivery, sex assigned at birth of infants, gestational weeks at the delivery, birth weight, group randomization, and infant age. The odds of having colic were also lower among infants who received some formula feed during the first week but then received breastmilk exclusively afterward compared with those received mix feeding since birth.
conclusionsWe observed the lower prevalence of colic among exclusive breastfeeding infants compared to those had mixed feeding. Further studies should be undertaken to examine the relationship between exclusive breastfeeding and infant colic.
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