ArticleOrphanet journal of rare diseases2026
Is hereditary angioedema associated with deficits in emotion regulation? A quantitative study in adult patients.
Article in Orphanet journal of rare diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with hereditary angioedema (HAE) exhibit emotional distress and a deteriorated quality of life. Emotional distress is associated with impaired emotional regulation, including alexithymia, which is characterized by difficulties in recognizing and expressing emotions. Our study assessed the presence of alexithymia in patients with HAE to determine whether patients with this disease experience difficulties and specific learning in emotion regulation. Thirty-nine adult patients with HAE answered a self-report questionnaire measuring: 1) alexithymia (Toronto Alexithymia Scale-20), 2) anxiety and depression symptoms (Hospital Anxiety and Depression Scale), 3) quality of life (Angioedema Quality of Life Questionnaire), 4) emotion regulation skills (Emotion Regulation Skills Questionnaire), 5) difficulties in emotion regulation (Difficulties in Emotion Regulation Scale), and 6) perceived quality of parental care (Parental Bonding Instrument).
resultsNo alexithymia was detected in 39.5% of patients, 36.8% of patients had definite alexithymia and 23.7% had possible alexithymia. Alexithymia was associated with fewer skills overall and more difficulties with emotion regulation, as well as with more depressive symptoms and lower quality of life in terms of fatigue/mood. Emotion regulation skills and difficulties also appeared to be associated with overprotection in terms of perceived paternal style.
conclusionsThis study shows a low prevalence of definite alexithymia in HAE patients and non-deficient emotion regulation. The association between alexithymia and depressive symptomatology suggests the potential role of interventions targeting emotion regulation features
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.