Evidence map›Paper›PMID 41680640›Full record

ArticleBMC geriatrics2026

Neutrophil-to-lymphocyte ratio as a predictor of in-hospital mortality in elderly emergency patients: a retrospective study from Southern Iran.

Latife Jabbari, Maryam Yousefzade, Saeed Hosseini Teshnizi, Leila Azizkhani, Saeed Hayati

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Article in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Latife JabbariDepartment of Emergency Medicine, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Maryam YousefzadeStudent Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Saeed Hosseini TeshniziDepartment of Community Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Leila AzizkhaniDepartment of Emergency Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Saeed HayatiDepartment of Emergency Medicine, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Saeed.hayati@hums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMortality risk stratification in older emergency department (ED) patients remains challenging in resource-limited settings, particularly among frail elderly with multiple comorbidities. This study evaluated the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in Southern Iran.

methodsIn this retrospective single-center study conducted between March 2021 and March 2022, we analyzed records of 2,540 consecutively admitted patients aged ≥ 65 years to an academic ED in Southern Iran. NLR was calculated from initial complete blood counts.

resultsAn NLR > 3.75 predicted in-hospital mortality with 52.2% sensitivity and 75.8% specificity (AUC = 0.655; 95% CI: 0.636–0.674; p < 0.001). Multivariate analysis confirmed NLR as an independent predictor (adjusted OR = 1.77; 95% CI: 1.28–2.44). An inverse association was observed between hypernatremia and mortality risk (OR = 0.68; 95% CI: 0.57–0.82).

conclusionsNLR > 3.75 may serve as a supportive and low-cost indicator for mortality risk stratification in elderly emergency patients; however, it should not be considered a stand-alone triage tool. The unexpected inverse association with hypernatremia warrants cautious interpretation and validation in future studies.

Indexed as

Emergency Service, HospitalHospital MortalityLymphocytesNeutrophilsAgedAged, 80 and overFemaleHumansIranLymphocyte CountMalePredictive Value of TestsPrognosisRetrospective StudiesEmergency triageNeutrophil-to-lymphocyte ratioOlder adultsPrognostic biomarkerResource-limited settings

Identifiers

PMID41680640
PMCPMC12964611

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