Evidence map›Paper›PMID 41680590›Full record

ArticleJournal of medicinal chemistry2026

Benzoic Acid Derivatives Improve Plasma Stability of Diester Butyrophilin Ligand Prodrugs.

Parker A Kintigh, Umed Singh, Girija Pawge, Sidra Bashir, Chia-Hung Christine Hsiao, Andrew J Wiemer, David F Wiemer

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Parker A KintighDepartment of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States.ORCID 0009-0008-1619-2023
Umed SinghDepartment of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States.ORCID 0000-0003-0683-7533
Girija PawgeDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.
Sidra BashirDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.
Chia-Hung Christine HsiaoDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.ORCID 0000-0002-9037-027X
Andrew J WiemerDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269-3092, United States.ORCID 0000-0002-3029-1780
David F WiemerDepartment of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States.ORCID 0000-0002-4881-8544

Funding

Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapyR01CA266138 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI ANDREW J WIEMER · 2022 to 2026
$1.8M
NCI NIH HHS R01 CA266138
6 · The paper itself

Abstract

The potent butyrophilin ligand, (

Indexed as

BenzoatesBenzoic AcidButyrophilinsProdrugsAnimalsDrug StabilityHumansK562 CellsLigandsOrganophosphatesStructure-Activity Relationship4-hydroxy-3-methyl-2-butenyl diphosphateBenzoatesBenzoic AcidButyrophilinsLigandsOrganophosphatesProdrugs

Identifiers

PMID41680590
PMCPMC12951462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.