Evidence map›Paper›PMID 41680582›Full record

ArticleAnnals of surgical oncology2026

Patient-Reported Outcome Measures Used in Primary Hyperparathyroidism: A Scoping Review.

Charlotte L Leblang, Mariem Ahmed, Carrie G Wade, Nancy L Cho, Gerard M Doherty, Matthew A Nehs, Jason B Liu

Abstract readScoping Review
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Charlotte L LeblangDepartment of Surgery, Lahey Hospital & Medical Center, Burlington, MA, USA.
Mariem AhmedPatient-Reported Outcomes, Value, and Experience Center, Mass General Brigham, Boston, MA, USA.
Carrie G WadeHarvard Medical School, Boston, MA, USA.
Nancy L ChoHarvard Medical School, Boston, MA, USA.
Gerard M DohertyHarvard Medical School, Boston, MA, USA.
Matthew A NehsHarvard Medical School, Boston, MA, USA.
Jason B LiuPatient-Reported Outcomes, Value, and Experience Center, Mass General Brigham, Boston, MA, USA. jbliu@mdanderson.org.ORCID http://orcid.org/0000-0002-7083-5703

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStandardized measuring tools, such as patient-reported outcome measures (PROMs), are needed to sufficiently measure the effect of an intervention or to describe patterns of disease. The extent to which PROMs have been used in primary hyperparathyroidism (PHPT) research is undefined. We conducted this scoping review to delineate the current landscape of PROMs used in research involving patients with PHPT.

methodsSix databases were systematically searched, and two independent reviewers identified all primary research articles that involved patients with PHPT and used PROMs. Characteristics of the identified studies and the PROMs were collated.

resultsWe examined 243 studies in full. Of these, 147 (49.7%) reported on symptoms or other health-related quality of life constructs that could be measured with PROMs but were not. In total, 96 (50.3%) studies used at least one PROM and were included. The median number of PROMs used per study was one (interquartile range 1-2), and 36 unique PROMs were identified. The three most frequently used PROMs were the 36-item Short Form Health Survey (42 studies), the Parathyroidectomy Assessment of Symptoms (20 studies), and the Beck Depression Inventory (12 studies). Symptoms and mental health constructs (e.g., anxiety, depression) were the most frequently assessed. Validity evidence for use in patients with PHPT was identified for only three PROMs: the 36-item Short Form Health Survey, Parathyroidectomy Assessment of Symptoms, and the Primary Hyperparathyroidism Quality of Life Questionnaire. All others were validated for use in patients without PHPT.

conclusionsThere are missed opportunities in the rigor of health-related quality of life measurement in PHPT research. Future clinical research should emphasize proper application of PROMs to attain valid conclusions.

Indexed as

Hyperparathyroidism, PrimaryPatient Reported Outcome MeasuresQuality of LifeHumansParathyroidectomyPrognosisHyperparathyroidismParathyroidectomyPatient-reported outcome measuresQuality of lifeQuestionnaireSurvey

Identifiers

PMID41680582
PMCPMC12982322

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.