ArticleDermatology and therapy2026
Metabolomics in Scalp Seborrheic Dermatitis Evidenced Key Changes in Inflammatory Markers Following a 10-Week Scalp Care Scheme with an Anti-dandruff Shampoo.
Article in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06578962 (Evaluation of the Effects of Shampoo RV3438G in Recurrent Squamous States and Maintenance of the Effects), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effects of Shampoo RV3438G in Recurrent Squamous States and Maintenance of the Effects
Who cites it
1 citing paper in PubMed.
- Lipidomic Insights into Seborrheic Dermatitis: Clinical Evaluation of Sebum Changes Using SpiderMass.Dermatology and therapy · 2026Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMild-to-moderate scalp seborrheic dermatitis (SD) is commonly managed by using anti-SD shampoos containing antifungal, anti-inflammatory, and keratolytic agents. A newly formulated anti-SD shampoo containing the patented combination of two antifungal actives has shown good clinical efficacy and tolerability in a previous two-phase randomized controlled trial.
methodsA specific analysis of scalp SD-associated metabolome was conducted to identify molecular markers involved in SD symptoms, and examine the impact of the anti-SD shampoo on these compounds. The intervention scheme involved a 2-week phase of intensive product use (three times a week), followed by an 8-week parallel-group maintenance phase consisting of the test group using the study shampoo once a week, and the control group using a neutral shampoo.
resultsFollowing the intensive phase of the intervention, a significant decrease in the levels of SD markers (cathepsin S, interleukin-8, and histamine), inflammatory lipids (arachidonic acid, linoleic acid, and oxylipins), and metabolites involved in tryptophan metabolism (indolacetate and indolelactate) was observed. These changes were sustained during the maintenance phase in the test group only, supporting the clinical efficacy of the anti-SD shampoo. The integrated analysis of metabolome and fungal microbiome data suggested a positive correlation between the level of Malassezia fungi and that of two oxylipins (9,10,13-triHOME and 9-HODE), highlighting the pivotal role of these lipolytic fungi in SD conditions, and the involvement of newly identified proinflammatory lipid mediators. These oxylipins could be used as novel targets for developing alternative anti-SD strategies.
conclusionThis approach allowed us to better characterize specific interactions within the scalp ecosystem providing deeper insights and unravelling new therapeutic pathways in SD like pro-inflammatory oxylipins. CLINICALTRIALS: GOV IDENTIFIER: NCT06578962 (retrospectively registered on August 28, 2024).
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