Evidence map›Paper›PMID 41680497›Full record

ArticleCommunications biology2026

Activation of cytomegalovirus-encoded G protein-coupled receptor UL33 by an innate N-terminal peptide.

Anna K Drzazga, Shota Suzuki, Caroline Wouters, Felix Faas, Kouki Nishikawa, Akiko Kamegawa, Yoshinori Fujiyoshi, Mette M Rosenkilde, Naotaka Tsutsumi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna K DrzazgaDepartment of Biomedical Sciences, Laboratory for Molecular and Translational Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6045-6320
Shota SuzukiAdvanced Research Initiative, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6516-8424
Caroline WoutersDepartment of Biomedical Sciences, Laboratory for Molecular and Translational Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0009-0007-0436-7124
Felix FaasDepartment of Biomedical Sciences, Laboratory for Molecular and Translational Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-2596-045X
Kouki NishikawaJoint Research Course for Advanced Biomolecular Characterization, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
Akiko KamegawaAdvanced Research Initiative, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.
Yoshinori FujiyoshiAdvanced Research Initiative, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-8070-1493
Mette M RosenkildeDepartment of Biomedical Sciences, Laboratory for Molecular and Translational Pharmacology, University of Copenhagen, Copenhagen, Denmark. rosenkilde@sund.ku.dk.ORCID http://orcid.org/0000-0001-9600-3254
Naotaka TsutsumiAdvanced Research Initiative, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan. tsutsumi.naotaka@tmd.ac.jp.ORCID http://orcid.org/0000-0002-3617-7145

Funding

Det Frie Forskningsråd (Danish Council for Independent Research) 6110-00688BJapan Agency for Medical Research and Development (AMED) JP21ae0121028Lundbeckfonden (Lundbeck Foundation) R242-2017-409MEXT | Japan Society for the Promotion of Science (JSPS) JP22K20632MEXT | Japan Society for the Promotion of Science (JSPS) JP24K18061MEXT | Japan Society for the Promotion of Science (JSPS) JP24K21935Novo Nordisk Fonden (Novo Nordisk Foundation) NNF20OC0062899
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) encodes the orphan G protein-coupled receptor (GPCR) UL33, which exhibits constitutive activity that disrupts host G protein signalling, facilitating efficient viral replication and pathogenesis. The cryo-electron microscopy (cryo-EM) structure of UL33 bound to the G

Indexed as

CytomegalovirusReceptors, ChemokineReceptors, G-Protein-CoupledViral ProteinsHumansPeptidesProtein ConformationSignal TransductionPeptidesReceptors, ChemokineReceptors, G-Protein-CoupledUL33 protein, human cytomegalovirusViral Proteins

Identifiers

PMID41680497
PMCPMC13009388

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.