ArticleExperimental & molecular medicine2026
Drug-induced gastrointestinal toxicity and barrier integrity: cytoskeleton-mediated impairment in a clinically relevant human intestinal epithelium model.
Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The mucosal-neural axis in chemotherapy-induced gastrointestinal toxicity.Oncology reviews · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Drug-induced gastrointestinal (GI) toxicity is common, dose-limiting and difficult to predict using conventional Caco-2-based assays that lack physiological relevance. Here we evaluate a transepithelial electrical resistance (TEER) assay using nontransformed human intestinal epithelial cells (hIECs), derived from human pluripotent stem cells, which superiorly recapitulated epithelial diversity and polarity as well as intestinal barrier function. Across 17 clinically relevant compounds (cell cycle inhibitors, tyrosine kinase inhibitors and nonsteroidal anti-inflammatory drugs), the hIEC TEER assay outperformed ATP cell viability assays, and the Caco-2 TEER assay (AUC of 0.96 for hIEC TEER, 0.72 for Caco-2 TEER and ≤0.69 for cell viability assays) correlated with integrated GI toxicity scores using a ≥50% TEER reduction cutoff (sensitivity 92%, specificity 100% and accuracy 94%). Drug exposure was quantified by calculating the margin of safety (IC
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