ArticleScientific reports2026
Optimization of the composition of temperature-responsive polymers for spin columns.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A straightforward method for deproteinizing serum samples is essential for treatment monitoring. In this study, a temperature-responsive spin column composed of various poly(N-isopropylacrylamide) (PNIPAAm) copolymer-modified bead-packed layers was developed. The optimal conditions for separating voriconazole, lamotrigine, and carbamazepine from the serum using the prepared columns were determined. Voriconazole was effectively separated using a bead-packed spin column modified with P(NIPAAm-co-N,N-dimethylacrylamide (DMAPAAm)7.5%-co-n-butyl methacrylate (BMA)0%) as the upper layer, which was attributed to the desorption of voriconazole at low temperatures. A high elution ratio was achieved for lamotrigine using a bead-packed spin column modified with P(NIPAAm-co-DMAPAAm7.5%-co-BMA0%). Conversely, a high carbamazepine elution ratio was obtained using P(NIPAAm-co-DMAPAAm7.5%–co-BMA5%). These findings indicate that the copolymer composition of temperature-responsive spin columns can be tailored for the separation of specific drugs.
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