Evidence map›Paper›PMID 41680362›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2026

Genetic risk stratification and preventive strategies for double primary HNSCC and ESCC: a single-center cohort study.

Sakiko Naito, Tomohiro Umezu, Hayato Yamaguchi, Takahiro Muramatsu, Yasuyuki Kagawa, Takashi Morise, Yoshiya Yamauchi, Isaku Okamoto, Masakatsu Fukuzawa, Kiyoaki Tsukahara and 2 more

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Article in Esophagus : official journal of the Japan Esophageal Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sakiko NaitoDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. rin.sooooo.sweety@gmail.com.ORCID 0000-0002-7533-1061
Tomohiro UmezuDepartment of Molecular Pathology, Tokyo Medical University, Tokyo, Japan.
Hayato YamaguchiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Takahiro MuramatsuDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Yasuyuki KagawaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Takashi MoriseDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Yoshiya YamauchiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Isaku OkamotoDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Masakatsu FukuzawaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Kiyoaki TsukaharaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Masahiko KurodaDepartment of Molecular Pathology, Tokyo Medical University, Tokyo, Japan.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHead and neck squamous cell carcinoma (HNSCC) and esophageal SCC (ESCC) share risk factors, such as alcohol consumption, smoking, and aldehyde dehydrogenase 2 (ALDH2) gene polymorphisms. However, the involvement of these factors in the occurrence of double primary cancers remains unclear. This study aimed to examine the risk factors for double cancers.

methodsThis single-center study analyzed 113 patients with HNSCC and ESCC diagnosed between 2014 and 2022, classified into four stage-based groups: Group A (early ESCC + early HNSCC), Group B (early ESCC + advanced HNSCC), Group C (advanced ESCC + early HNSCC), and Group D (advanced ESCC + advanced HNSCC). Associations among clinical factors, Lugol-voiding lesions (LVLs), and prognosis were evaluated. Genetic analyses of ALDH2, CYP2A6, and ADH1B were performed in 20 patients, and multivariate Cox analysis included tumor stage, smoking, and body mass index (BMI).

resultsSmoking was more common in Group B than in Group A (89.0% vs. 73.5%, p = 0.013) and was associated with Lugol-voiding lesions (p = 0.027). Three-year overall survival declined with advancing stage (93.3%, 74.0%, 33.3%, and 36.4% for Groups A-D; p < 0.001). Multivariate analysis identified advanced stage, smoking (HR = 1.9, p = 0.009), and low BMI (< 18.5 kg/m

conclusionsHeavy smoking was associated with the development of LVLs and poor prognosis in those with double primary cancers. ALDH2 and CYP2A6 may contribute to cancer risk, underscoring the importance of abstinence from alcohol and smoking in preventive healthcare.

Indexed as

Aldehyde Dehydrogenase, MitochondrialEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaNeoplasms, Multiple PrimarySquamous Cell Carcinoma of Head and NeckAgedAlcohol DehydrogenaseAlcohol DrinkingBody Mass IndexCohort StudiesCytochrome P-450 CYP2A6FemaleHumansMaleMiddle AgedNeoplasm StagingADH1B protein, humanAlcohol DehydrogenaseAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanCYP2A6 protein, humanCytochrome P-450 CYP2A6ALDH2 geneCYP2A6 geneDouble cancerEsophageal squamous cell carcinomaHead and neck cancer

Identifiers

PMID41680362
PMCPMC13038666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.