Evidence map›Paper›PMID 41680293›Full record

ArticleNature plants2026

A feedback regulatory loop by MAPK-CCA1 engages auxin signalling to stimulate root foraging for nitrate.

Xiaofei Zhang, Shanmin Zhou, Jingyi Guo, Ricardo F H Giehl, Xiaodong Xu, Lixing Yuan, Fusuo Zhang, Malcolm J Bennett, Nicolaus von Wirén, Zhongtao Jia

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Xiaofei Zhang *State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development, China Agricultural University, Beijing, China.
Shanmin Zhou *State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development, China Agricultural University, Beijing, China.
Jingyi GuoMolecular Plant Nutrition, Department of Physiology & Cell Biology, Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany.
Ricardo F H GiehlMolecular Plant Nutrition, Department of Physiology & Cell Biology, Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany.ORCID http://orcid.org/0000-0003-1006-3163
Xiaodong XuState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.ORCID http://orcid.org/0000-0002-8795-7651
Lixing YuanState Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0003-0233-6184
Fusuo ZhangState Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0001-8971-0129
Malcolm J BennettFuture Food Beacon and School of Biosciences, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0003-0475-390X
Nicolaus von WirénMolecular Plant Nutrition, Department of Physiology & Cell Biology, Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany. vonwiren@ipk-gatersleben.de.ORCID http://orcid.org/0000-0002-4966-425X
Zhongtao JiaState Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development, China Agricultural University, Beijing, China. jiazt@cau.edu.cn.ORCID http://orcid.org/0000-0003-0233-1578

Funding

China Agricultural University (CAU) 2023RC052, 1031-00114341, 2025RC027Ministry of Agriculture and Rural Affairs of the People's Republic of China (MOA) 2023ZD04072Ministry of Education of the People's Republic of China (Ministry of Education of China) 00975101National Natural Science Foundation of China (National Science Foundation of China) 32370270
6 · The paper itself

Abstract

In eucaryotes, mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved signalling modules crucial for growth regulation and stress tolerance. However, the regulatory role of MAPK in nutrient sensing by plants remains largely unclear. Here we uncovered MEKK14 and its paralogue MEKK13 determine lateral root elongation via enhanced cell division and expansion. We further fine-mapped a naturally occurring histidine-to-glutamine substitution in MEKK14 that weakens protein kinase activity and attenuates lateral root growth and response to nitrate (NO

Indexed as

ArabidopsisArabidopsis ProteinsIndoleacetic AcidsMitogen-Activated Protein KinasesNitratesPlant RootsTranscription FactorsFeedback, PhysiologicalGene Expression Regulation, PlantPhosphorylationSignal TransductionArabidopsis ProteinsIndoleacetic AcidsMitogen-Activated Protein KinasesNitratesTranscription Factors

Identifiers

PMID41680293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.